KIF4A

KIF4A

A gene on chromosome Xq13.1 that encodes an ATP-dependent, microtubule-based motor protein involved in the intracellular transport of membranous organelles. KIF4A translocates the protein regulator of cytokinesis 1 (PRC1) to the plus ends of interdigitating spindle microtubules during the metaphase-to-anaphase transition, which is an essential step in forming an organised central spindle midzone and midbody and in successful cytokinesis. KIF4A may play a role in mitotic chromosomal positioning and bipolar spindle stabilisation.
References in periodicals archive ?
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.
Other genes including BIRC5, an inhibitor of apoptosis; KIF4A, an ATP (adenosine triphosphate) dependent microtubule-based motor protein; and SEPT9, a member of the septin family involved in cytokinesis and cell cycle control, were upregulated and associated with poor prognosis.