KDM6B

KDM6B

A gene on chromosome 17p13.1 that encodes lysine-specific demethylase 6B, which demethylates histone H3 and is involved in regulating posterior development by regulating HOX gene expression. KDM6B participates in inflammation by regulating gene expression and macrophage differentiation.
References in periodicals archive ?
In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates.
The assay uses the company's biomarker development platform to provide concurrent in-vitro identification of antibodies against domains of Scl-70 (topoisomerase I), CENP-B, KDM6B and BICD2, within human serum or plasma.
He and his team found that KDM4B and KDM6B, two gene-activating enzymes, can promote stem cells' differentiation into bone cells by removing methyl markers from histone proteins.
The research group, through its study of aging mice, found that the two enzymes KDM4B and KDM6B could specifically activate genes that promote stem cell differentiation toward hone, while blocking the route toward fat.
Interestingly, in our aged mice, as well as osteoporotic mice, we observed a higher amount of silencing histone methyl groups which were normally removed by the enzymes KDM4B and KDM6B in young and healthier mice," Wang said.