KCNQ4

KCNQ4

Notation for a gene for DFNA2.

KCNQ4

A gene on chromosome 1p34 that encodes a K+ channel which regulates neuronal excitability, especially in the sensory cells of the cochlea. The current is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, an anti-convulsant. KCNQ4 protein can form a homomultimeric K+ channel or heteromultimeric K+ channel with the KCNQ3 protein product.

Molecular pathology
KCNQ4 mutations are associated with non-syndromic sensorineural deafness type 2.
References in periodicals archive ?
Most cases of ADNSHHI are characterized by postlingual progressive sensorineural hearing loss, with the age of onset mostly being in the second or the 3 [sup]rd year, such as is the case with KCNQ4 , [sup][11] GJB3 , [sup][12] and MYH14 .
Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss.
KCNQ4, a novel potassium chananel expressed in sensory outer hair cells, is mutated in dominant deafness.
Now they hope the KCNQ4 gene find paves the way for drugs to prevent deafness - and bring relief to Britain's 6.
Significant differences between susceptible and resistant workers were found in the sequence of three genes - KCNE1, KCNQ1 and KCNQ4.
Now they hope the KCNQ4 gene discovery paves the way for drugs to prevent deafness and bring relief to Britain's 6.