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Joffroy's sign

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia, Hutchinson 0.06 sec.
Jof·froy's sign (zhô-frwäz)
n.
1. An indication of exophthalmic goiter in which the facial muscles remain immobile when the eyeballs are rolled upward.
2. An indication of the early stages of brain disease in which an individual is unable to mentally compute simple mathematical calculations.

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