SMAD4

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SMAD4

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD4 forms homomeric complexes and heteromeric complexes with other activated SMADs; these accumulate in the nucleus and regulate target gene transcription. SMAD4 binds to DNA and recognizes an 8-bp palindromic sequence, the SMAD-binding element (SBE).
 
Molecular pathology
SMAD4 mutations or deletions are linked to hereditary haemorrhagic telangiectasia syndrome, juvenile polyposis syndrome and pancreatic cancer.
References in periodicals archive ?
Once the technical hurdles are cleared, the concept's economic viability will be analysed using relevant and realistic cases provided by the JIP partners.
Anyone who can offer Jip or Monty a home is asked to call the Scottish SPCA's Lanarkshire centre on 03000 999 999.
With respect to specific force development actions, the 2014 JIP includes activities related only to the 10 highest priority JOAC required capabilities due to the scope and magnitude of the task at hand in relation to the time available to develop the first iteration of the plan.
JIP chief Siraj ul Haq urged government to allow pti and pat observing their constitutional and democratic demonstrative long marches as the prevailing law completely entitle them for such protest.
Sony says "the Company has determined that concentrating its mobile product lineup on smartphones and tablets and transferring its PC business to a new company established by JIP is the optimal solution.
The parties' current intention is to sell Sony's PC business and certain related assets to a new company established by JIP, targeting July 1, 2014 for the completion of the Sale.
The JIP will focus on the following key issues: relationships between facies, depositional sequences and reservoir quality; shale pore types and their effect on total porosity and permeability; porosity-permeability trends for individual Utica and Point Pleasant facies; relative permeability and capillary pressure behavior; and linking core-derived reservoir quality to well logs and well productivity.
The JIP is managed by DNV and is co-sponsored by DNV along with nine industry Parties and Authorities, namely the Australian Maritime Safety Authority (AMSA), BOC Limited (Linde Group), Farstad Shipping Pty.
Meet a pushmi-pullyu, read a story with a chimp or play with Jip, an Old English Sheepdog.
The JIP offers qualifications in the areas of sustainable energy, leadership and management, business improvement techniques and logistics--all of which can have an immediate impact on improving the energy efficiency of a business; however it is also the industry specific qualifications that can really put a stamp on the way a company operates throughout.
Hassib Hussein Osseiran died on Saturday and his mother Zohour Osseiran [MP Osseiran's sister] was critically wounded after their russet Toyota Runner 4 Jip crashed in a nearby open space.
RSGT the only terminal at JIP designed to the next generation of super-mega vessels of 13,000+ TEUs adding an annual capacity of up to handle two million twenty- foot-equivalent units (TEU) annually to the existing port.