ocriplasmin

(redirected from Jetrea)

ocriplasmin

(ok-plas-min) ,

Jetrea

(trade name)

Classification

Therapeutic: ocular agents
Pharmacologic: enzymes
Pregnancy Category: C

Indications

Symptomatic treatment of vitreomacular adhesion (VMA).

Action

A proteolytic enzyme that dissolves the protein matrix present in vitreomacular adhesions.

Therapeutic effects

Dissolution of vitreomacular adhesion with improved vision.

Pharmacokinetics

Absorption: Minimal absorption
Distribution: Action is primarily local
Metabolism and Excretion: Rapidly degraded following administration
Half-life: Unknown.

Time/action profile (VMA resolution)

ROUTEONSETPEAKDURATION
Intravitrealwithin 1 wk3 wk6 mos or more

Contraindications/Precautions

Contraindicated in: None noted.
Use Cautiously in: Lactation: Effects are not know, use caution Obstetric: Use during pregnancy only if clearly needed Pediatric: Safe and effective use in children has not been established

Adverse Reactions/Side Effects

May be due to procedure

Ear, Eye, Nose, Throat

  • blurred vision (most frequent)
  • conjunctival hemorrhage (most frequent)
  • ↓ visual acuity (most frequent)
  • eye pain (most frequent)
  • macular hole (most frequent)
  • vitreous floaters (most frequent)
  • retinal edema (most frequent)
  • anterior chamber cell
  • cataract
  • conjunctival hyperemia
  • dry eye
  • dyschromatopsia (yellow vision)
  • ↑ intraocular pressure
  • intraocular inflammation/infection
  • intraocular hemorrhage
  • iritis
  • lens subluxation
  • macular edema
  • metamorphopsia (distorted vision)
  • photophobia
  • photopsia (perceived light flashes)
  • retinal degeneration
  • retinal detachment
  • vitreous detachment

Interactions

Drug-Drug interaction

None noted.

Route/Dosage

Intravitreal (Adults) 0.125 mg injected as a single dose

Availability

Solution for intravitreal injection: 0.5 mg/0.2 mL

Nursing implications

Nursing assessment

  • Monitor for elevation in intraocular pressure following injection.
  • Monitor visual acuity periodically following injection; may lead to decrease in vision.

Potential Nursing Diagnoses

Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • Ocriplasmin must be administered by a qualified physician.
  • Intravitreal: Remove vial from freezer and allow to thaw for few min at room temperature. Add 0.2 mL of preservative free 0.9% NaCl. Swirl gently until mixed. Solution is clear and colorless without particles; do not administer solutions that are discolored or contain particulate matter. Withdraw all solution from vial with a 19 gauge needle. Replace needle with 30 gauge needle and expel excess air and solution to 0.1 mL. Discard unused solution. Administer adequate anesthesia and a broad spectrum antibiotic as per protocol. Intravitreal injection is done via aseptic technique. Repeat administration in same eye is not recommended.
    • Wait 7 days before treating other eye if necessary.

Patient/Family Teaching

  • Explain procedure for intravitreal injection to patient.
  • Advise patient to notify health care professional immediately if signs and symptoms of intraocular inflammation/infection (eye redness, sensitivity to light, eye pain, change in vision) occurs.
  • May cause visual changes. Advise patient to avoid driving and other activities requiring good vision until response to medication is known.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Improved vision in patients with vitreomacular adhesions.
References in periodicals archive ?
Our study forecasts revenues of five prominent brands: - Lucentis - Eylea - Avastin - Visudyne - Jetrea.
Our study forecasts sales of 27 marketed drugs, including these brands: -- Lucentis -- Eylea -- Restasis -- Vigamox -- Pataday/ Patanol -- Jetrea -- Lumigan and Ganfort -- Xalatan/Xalacom -- Zioptan -- Cravit
April 23 (SeeNews) - Belgian biopharmaceutical firmA ThromboGenicsA NV (EBR:THR) said Thursday it is evaluating its eye drug Jetrea as a potential treatment for retinal vein occlusion (RVO), which is the product's third indication.
Alcon presented further efficacy and safety data for the use of Jetrea at EURETINA.
THE NATIONAL Institute for Care and Health Excellence (NICE) has recommended Jetrea (ocriplasmin) for patients with vitreomacular traction (VMT).
400 Pharmaceuticals Thrombogenics Jetrea Symptomatic
Our study forecasts sales of 27 marketed drugs, including these brands: - Lucentis - Eylea - Restasis - Vigamox - Pataday/ Patanol - Jetrea - Lumigan and Ganfort - Xalatan/Xalacom - Zioptan - Cravit Discover how high revenues can go.
Our study forecasts revenues of five prominent brands : -- Lucentis -- Eylea -- Avastin -- Visudyne -- Jetrea.
SeeNews) - Sep 9, 2014 - Belgian biopharmaceutical firmA ThromboGenicsA NV (EBR:THR) said Monday it had received approval to sell its eye drug Jetrea in South Korea for the treatment of adults with symptomatic vitreomacular adhesion (VMA).
Jetrea, the one-time single eye injection which is licensed in the UK to treat vitreomacular traction (VMT), including macular hole, has received an initial positive recommendation from the National Institute for Health and Clinical Excellence (NICE).
SeeNews) - Jun 25, 2014 - Belgian biopharmaceutical firmA ThromboGenicsA NV (EBR:THR) is no longer up for sale but will continue looking for a partner to commercialise its eye drug Jetrea in the US, the company said Tuesday.
Belgium-based biopharmaceutical firm ThromboGenics has declared that its partner Alcon has introduced Jetrea (ocriplasmin) for the cure of symptomatic vitreomacular adhesion (VMA) in Canada.