Jamaican vomiting sickness(redirected from Jamacian vomiting sickness)
an acute and frequently fatal vomiting disease associated with central nervous system symptoms and marked hypoglycemia, caused by eating unripe ackee fruit of Blighia spaida, a tree common in Jamaica.
Synonym(s): Jamaican vomiting sickness
Jamaican vomiting sicknessAn intoxication by “bush tea” made from unripe fruit of the Jamaican ackee tree (Blighia sapida), which is caused by hypoglycin, a propionic acid derivative that inhibits isovaleryl CoA dehydrogenase, provoking violent vomiting, prostration, drowsiness, convulsions and hypoglycaemia as low as 0.56 mmol/L (US: 10 mg/dl).
High; death often occurs within 24 hours of ingestion.
The condition is caused by the metabolites of hypoglycin A, an amino acid that is converted to coenzyme A thioesters and carnitine derivatives; these sequester intracellular carnitine and inhibit fatty acid oxidation, causing accumulation of isovaleric acid with continued fatty acid esterification, resulting in fine-droplet fatty liver.