KDM5B

(redirected from JARID1B)

KDM5B

A gene on chromosome 1q32.1 that encodes lysine-specific demethylase 5B, which interacts with FOXG1 and PAX9 as a transcriptional co-repressor. Lysine K-specific methylase may act as a tumour suppressor for melanoma.

Molecular pathology
KDM5B favours breast cancer cell proliferation by repressing tumour suppressor genes BRCA1 and HOXA5.
References in periodicals archive ?
Drug development targeting the histone demethylase JARID1B
In this way, JARID1B is a powerful regulator of gene expression and is also involved in normal tissue development as well as the maintenance of cancer stem cells.
JARID1B belongs to a family of Jarid1 proteins that are highly homologous, and there is at least partial redundancy between Jarid1b and Jarid1a in demethylating H3K4.
In colorectal cancer cell lines, we confirmed that knockdown of JARID1B compromised the growth of the tumours in the mouse xenograft model, as well as reducing the sphere forming capacity, suggesting the functional significance of JARID1B in cancer stem cells.
We are therefore at present searching for small molecule inhibitors of JARID1B, with the aim of developing a drug that could be used clinically for the eradication of cancer stem cells.
Other examples of tumor cell plasticity include the demonstration that melanoma cells expressing the histone demethylase JARID1B are required for continuous tumor growth, and that such JARID1B-positive cells can spontaneously arise from JARID1B-negative cells (57).