KDM5B

(redirected from JARID1B)

KDM5B

A gene on chromosome 1q32.1 that encodes lysine-specific demethylase 5B, which interacts with FOXG1 and PAX9 as a transcriptional co-repressor. Lysine K-specific methylase may act as a tumour suppressor for melanoma.

Molecular pathology
KDM5B favours breast cancer cell proliferation by repressing tumour suppressor genes BRCA1 and HOXA5.
References in periodicals archive ?
Other examples of tumor cell plasticity include the demonstration that melanoma cells expressing the histone demethylase JARID1B are required for continuous tumor growth, and that such JARID1B-positive cells can spontaneously arise from JARID1B-negative cells (57).