ito cell


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ito cell

One of numerous star-shaped cells lying in the spaces between the main liver cells (hepatocytes) and the blood channels (sinusoids) that store vitamin A.

ito cell

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05), whereas Ito cell lipid accumulation was highly related to age (p < 0.
It has been proposed that this displacement is related to the high vitamin A accumulation (natural storage) in Ito cell cytoplasmic lipid droplets and hepatocytes, accumulated through the extensive feeding on blubber from ringed seal and bearded seal (Kakela et al.
1992; Ramsay and Stirling 1988), and a seasonal pattern in Ito cell numbers may be expected as was the case for the fatty tissue lipid percentage (Dietz et al.
If the Ito cell number reflects the vitamin A exposure through marine prey species, mainly ringed seal and bearded seal (Ramsay and Stirling 1988), young bears would have lower numbers of Ito cells because they do not start eating prey rich in vitamin A until they are weaned at approximately 2 years of age (Derocher and Stirling 1994).
A cellular basis for high-levels of vitamin-A in livers of polar bears (Ursus maritimus)--the Ito cell.
Light microscopic changes consisted of nuclear displacement from the normal central cytoplasmic location in parenchymal cells, mononuclear cell infiltrations (mainly portally and as lipid granulomas), mild bile duct proliferation accompanied by fibrosis, and fat accumulation in hepatocytes and pluripotent Ito cells.
In the case of Ito cells and bile duct hyperplasia accompanied by portal fibrosis, we performed the chisquare test within subadult, adult, and old bears to determine age dependency.
In the case of lipid granulomas, the relationship to OHCs was analyzed based on the presence or absence of Ito cells.
Finally, we found a trend of livers with visible Ito cells showing a larger frequency of fatty granulomas, compared with livers without visible Ito cells (p < 0.
The fact that liver tissue, rich in visible Ito cells, had a higher number of lipid granulomas indicates that microorganisms (originating from the blood supply) play a role in the random multifocal necrosis (rupture of Ito cells) observed (Kelly 1993; MacLachlan and Cullen 1995).