ITGAM


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ITGAM

A gene on chromosome 16p11.2 that encodes the integrin alpha M chain, which combines with the beta-2 chain (ITGB2) to form a leukocyte-specific integrin, macrophage receptor 1 (Mac-1), or inactivated C3b receptor 3 (CR3).
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References in periodicals archive ?
Se identifico al rs1143679 como el SNP mas probable dentro del gen ITGAM asociado a LES en pacientes europeos e hispanoamericanos (principalmente mexicanos).
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Work by Nath and colleagues published concurrently (46) demonstrates that the ITGAM association is present in patients of both European and African descent, and that the likely causal variant is a nonsynonymous SNP (rs1143679) that converts the normal arginine at amino acid position 77 to a histidine (R77H).