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Itai-Itai Disease
(redirected from Itai-itai)

   Also found in: Wikipedia 0.01 sec.
Itai-Itai Disease
A form of renal osteodystrophy—osteomalacia with marked bone pain and painful fractures—described in multiparous Japanese women due to cadmium accumulation in bone, caused by industrial pollutants


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The toxic effect of cadmium on bone became evident at the outbreak of Itai-itai disease in Japan, where severe renal and skeletal damage in women was associated with consumption of heavily cadmium-polluted rice (Kjellstrom 1992).
Cadmium, a toxic metallic element, is known to be the cause of Itai-itai Disease, considered to be a type of acquired Fanconi Syndrome characterized by kidney dysfunction and osteomalacia, which plagued a number of people, mainly women, in Toyama Prefecture in the 1950s.
Cadmium is known to be the cause of Itai-itai Disease, considered to be a type of acquired Fanconi Syndrome characterized by kidney dysfunction and osteomalacia, which plagued a number of people, mainly women, in Toyama Prefecture in the 1950s.
 
 
 
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