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Isotretinoin

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isotretinoin /iso·tret·i·noin/ (i?so-tret´in-o-in) a synthetic form of retinoic acid, used orally to clear cystic and conglobate acne.
i·so·tret·i·no·in (s-trtn-oin)
n.
A chemical compound that inhibits the secretion of sebum and is used in the treatment of severe forms of acne.
Isotretinoin
A powerful vitamin A derivative used in the treatment of acne. It can promote scarring after skin resurfacing procedures.
Mentioned in: Acne, Skin Resurfacing
isotretinoin
(ī´sōtret´inoin),
n brand name: Accutane;
drug class: retinoic acid isomer, vitamin A derivative;
action: decreases sebum secretion, improves cystic acne;
uses: severe recalcitrant cystic acne.
isotretinoin
a synthetic form of retinoic acid (13-cis-retinoic acid), used in dermatology for the treatment of disorders of keratinization. It is a potent teratogen.
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However, anecdotal complaints linking isotretinoin to depression and suicide have left some doctors and patients concerned about the drug's safety.
Acne drug affects brain function by Science News
In utero exposure to isotretinoin (13-cisretinoic acid), an analog of vitamin A used to treat cystic acne, is associated with a characteristic pattern of malformations, including abnormal ear development, a flat nasal bridge, mandibular hypoplasia, cleft palate, hydrocephalus, neural tube defects, and conotruncal heart defects (Lammer et al.
Children's health and the environment: public health issues and ... by Eskenazi, Brenda / Environmental Health Perspectives
For patients with severe inflammatory acne that does not improve with other medications, such as those described above, isotretinoin (Accutane), a retinoid, may be needed.
Questions and Answers About Acne by Pamphlet by: Nat'l Inst. of Arthritis and Musculoskeletal & Skin Diseases
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