Cell cycle arrest by the isoprenoids
perillyl alcohol, geraniol, and farnesol is mediated by p21(Cipl) and p27(Kipl) in human pancreatic adenocarcinoma cells.
Two indole-alkaloid isoprenoids
were isolated from extracts of Penicillium crustosum grown on rice, and their chemical structures are related to penitrems.
Some algae, bacteria, and plants, however, make isoprenoids
by employing another set of enzymes.
Several biomarkers, including n-alkanes, acyclic isoprenoids
, terpenoids and steroids, were detected in all samples (Figs.
And bacterial cell walls are made using isoprenoids
Limonene and lycopene are examples of isoprenoids
that inhibit cancer.
Apomine is thought to exert its cancer-fighting effect by lowering the production of isoprenoids
, which in turn inhibit the action of ras.
He L, Mo H, Hadisusilu S, Quresni AA, Elson CE (1997) Isoprenoids
suppress the growth of murine B16 melanomas in vitro and in vivo.
Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids
in Plasmodium falciparum.
However, it is now clear that the mevalonate pathway is the unique source for isoprenoids
in animals and certain eubacteria, whereas many eubacteria including most human pathogens use exclusively the non-mevalonate pathway [for review, see Boucher and Doolittle, 2000; Eisenreich et al.
Cytotoxic flavonoids with isoprenoids
groups from Morus mongolica.
While synthetic biology can be used to create any number of useful chemicals called isoprenoids
that form the basis for products such as perfumes and flavorings, Keasling has chosen to focus on the creation of much-needed pharmaceuticals, such as artemisinin, for the developing world.