b) Incubated tracheal chains 30 min prior to the beginning and while obtaining the isoprenaline curve with 1 [mu]M chlorpheniramine maleate (Sigma Chemical Ltd.
50], the slope of the curves, the values of (CR-1) and maximum response to isoprenaline in different experiments were expressed as mean [+ or -] SEM.
Cumulative log concentration-response curves of isoprenaline obtained in the presence of only higher concentration of the extract showed clear leftward shift compared to the curve in the presence of saline in group 1.
50] of isoprenaline obtained in the presence of propranolol in both experimental conditions were significantly higher than those for saline (p < 0.
50] ([mu]M) of isoprenaline in the presence of aqueous-ethanolic extract from Crocus sativus, safranal, 10nM propranolol, and saline in two sets of experiments Solutions Concentration Group 1 Group 2 Stat.
The maximum response to isoprenaline obtained in the presence of both concentrations of the extract and safranal in group 1 was significantly lower than that of saline (p < 0.
There was also no significant difference in the slopes of isoprenaline curve obtained in the presence of saline, two concentrations of the extract, safranal and propranolol between the two groups of experiments and also between two concentrations of the extract and safranal (Table 3).
50] of isoprenaline obtained in the presence of both concentrations of the extract from Crocus sativus in group 2 were significantly lower than those of safranal (p < 0.
The results on non-incubated trachea (group 1) showed a small parallel leftward shift of the isoprenaline concentration-response curves in the presence of only higher concentration of the extract of Crocus sativus compared to the curve in the presence of saline which indicated stimulatory effect of the extract on[[beta].