isometheptene


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isometheptene

A SYMPATHOMIMETIC drug used to treat MIGRAINE. A brand name of a preparation with paracetamol is Midrid.

isometheptene

a sympathomimetic drug, used parenterally as the hydrochloride or orally as the mucate, as a smooth muscle relaxant.
References in periodicals archive ?
United States-based Tonix Pharmaceuticals has received approval from the US Food and Drug Administration for its new drug application to assess TNX-201, a single isomer of isometheptene to treat episodic tension-type headache, it was reported today.
At the time of evaluation with the headache clinic, she was on topiramate, magnesium, combination of isometheptene mucate, dichloralphenazone, and acetaminophen and as needed oxycodone, which she used 2-3 tablets per week.
0 (a) Camylofin, trimebutine, papaverine, isometheptene, alverine, hyoscyamine, belladonna alkaloids.
The ingredient isometheptene, found in Midrin, an over-the-counter medication used to treat migraines, was also reported to cause postpartum cerebral angiopathy when it was taken in excess of the recommended amount (Raroque, Tesfa, & Purdy, 1993).
Many other drugs have been used in treating migraines, including: acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; meperidine; intranasal butorphanol (Stadol); and corticosteroids.
Numerous other drugs have been used in treating migraines, including acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; and meperidine.
Other migraine drugs include acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone): NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; meperidine; intranasal butorphanol (Stadol); and corticosteroids.
The United States Headache Consortium has determined that the combination of isometheptene, acetaminophen, and dichlorphenazone (Midrin), though not as effective as the triptans, may be useful in treating mild-to-moderate migraine.
In addition to the triptans, aspirin, ergotamines, and isometheptene should be avoided.
A multicenter, double-blind, randomized parallel group study (8) showed no difference between the combination product isometheptene mucate, dichloralphenazone with acetaminophen (Midrin, Duradrin, etc) (used as recommended in the package insert with a maximum of up to 5 tablets within 24 hours) vs oral sumatriptan (initial dose of 25 mg with a repeat 25 mg dose in 2 hours).
Midrin--a capsule headache formulation that combines an analgesic, acetaminophen; a sedative, dichloralphenazone; and a vascular constrictor, isometheptene mucate--was as effective as oral sumatriptan for re-solving migraine headaches in a study with 126 patients, reported Dr.
17-19) However, the lack of standardized inclusion criteria and outcome measures makes it difficult to draw finn, valid conclusions about the efficacy of isometheptene.