isoenzyme

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isoenzyme

 [i″so-en´zīm]
any of several forms of an enzyme that all catalyze the same reaction but may differ in reaction rate, inhibition by various substances, electrophoretic mobility, or immunologic properties. Several enzymes, particularly alkaline phosphatase, lactate dehydrogenase, and creatine kinase, have clinically important isoenzymes. Isoenzymes are separated by electrophoresis, and the pattern indicates which damaged organ has released the enzymes.

i·so·en·zyme

(ī'sō-en'zīm),
An enzyme (one of a group) that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation, for example, lactate dehydrogenase, a tetramer composed of varying amounts of α and β subunits (that is, 4α, 3α + 1β, 2α + 2β, 1α + 3β, and 4β).
Synonym(s): isozyme

isoenzyme

/iso·en·zyme/ (-en´zīm) isozyme.

isoenzyme

(ī′sō-ĕn′zīm′)
n.
An isoform that is an enzyme.

i′so·en·zy′mic adj.

isoenzyme

[ī′sō·en′zīm]
Etymology: Gk, isos + en, in, syme, ferment
a chemically distinct form of an enzyme. The various forms are distinguishable in analysis of blood samples, which aids in the diagnosis of disease. Different enzymes that catalyze the same physiological reaction may also exist as isoenzymes in different animal species. Also called isozyme.

i·so·en·zyme

(ī'sō-en'zīm)
One of a group of enzymes that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation.

isoenzyme (isozyme)

one of a number of ENZYMES that catalyse the same reaction, but are qualitatively different from each other, for example in PRIMARY STRUCTURE.

Isoenzyme

One of a group of enzymes that catalyze the same reaction but are differentiated by variations in physical properties.

isoenzyme

any of the several forms of an enzyme, all of which catalyze the same reaction, but which may differ in reaction rate, inhibition by various substances, electrophoretic mobility or immunological properties. Several enzymes, particularly alkaline phosphatase, lactate dehydrogenase and creatine kinase, have clinically important isoenzymes. Isoenzymes are separated by electrophoresis, and the pattern indicates which damaged organ has released the enzymes.
References in periodicals archive ?
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the phosphocreatine circuit for cellular energy homeostasis.
Copper induction of laccase isoenzymes in the ligninolytic fungus Pleurotus ostreatus.
From that observation, it follows that the PXN/AE activity ratio can be used as an interpolation index to estimate the relative amounts of total PON1 hydrolytic activity attributable to each of the Q and R isoenzymes in QR heterozygous individuals (18).
Inhibiting specific isoenzymes in tumors may be a way to selectively hit cancer cells without affecting normal cells, which could get by with other isoenzymes," said Dr.
The LD1 isoenzyme will be purified from human erythrocytes.
Uselfulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage and inflammation.
Each time the mineral nutrient environment of the peanut was changed, the accompanying oxidative stress fragmented some of the GDH polypeptides [13], then the intact polypeptides rearranged themselves to form a new set of hexameric isoenzymes [8, 22, 23], followed by their synthesis of a new pool of RNA (Fig 1).
CK-MB is one of three isoenzymes arising from total creatine kinase (CK).
Lu AA21004 is extensively metabolized in the liver, with at least 5 cytochrome P450 isoenzymes involved.
He hypothesized that the G6PD subtype could have changed because of multiple divisions in culture, but he later demonstrated the stability of isoenzymes in cell culture lines over time.
As most chemotherapy agents undergo metabolism in the body through the CYP450 (Cytochrome P-450) pathway, this parameter was investigated in combination with four isoenzymes (3A4, 2C8, 2C9 and 2D6).