The eight enzymatic systems analyzed were Aspartate Amino Transferase (AAT), Acid Phosphatase (ACP), Glucose Dehydrogenase (GDH), Glucose 6-Phosphate Isomerase (GPI), Isocitrate
Dehydrogenase (IDH), Malate Dehydrogenase (MDH), Malic Enzyme (ME) and Phosphoglucomutase (PGM)
The activities of hepatic mitochondrial enzymes such as isocitrate
dehydrogenase (ICH) a-ketoglutarate dehydrogenase (KDH) succinate dehydrogenase (SH) malate dehydrogenase (MDH) NADPH dehydrogenase and cytochrome C oxidase were significantly decreased in CCl4- hepatotoxic rats and administration of corosolic acid brought back these parameters towards normal.
The product is used to treat patients with acute myelogenous leukemia that harbour an isocitrate
dehydrogenase-2 (IDH2) mutation.
Of respiratory enzymes, lactate dehydrogenase remained unaffected in both populations but isocitrate
dehydrogenase (ICDH) activity showed significant increase (87%) in resistant and decrease (81%) in susceptible populations.
A notable example is the enzyme isocitrate
Activities of NADP-ICDH and NADH-GDH in tomato leaves: In higher plants, NADP-dependent isocitrate
dehydrogenase (NADPH-ICDH) provides C-skeletons in the form of 2-oxoglutarate, which requires for both the activities of GS/GOGAT cycle enzymes and/or the activity of NADH-GDH to synthesize glutamate.
dehydrogenase), except 50 mM Tris/HCl buffer (pH 7.
A similar mechanism of inhibition has been reported for other enzymes inhibited by Cd, such as Oggl and nicotinamide adenine dinucleotide phosphate-dependent isocitrate
dehydrogenase (Kil et al.
The partial sequences for the mitochondrial enzymes of the TCA cycle such as aconitase (AT) and isocitrate
dehydrogenase (ICD) were also isolated.
net/cgi-bin/mlst7/ index) uses PCR primers to amplify internal segments of 7 specific housekeeping genes (aspartate aminotransferase [aspC], caseinolytic protease [clpX], acyl-CoA synthetase [fadD], isocitrate
dehydrogenase [icdA], lysine permease [lysP], malate dehydrogenase [mdh] and uidA), which are purified and sequenced.
Four of 16 allozyme loci, creatine kinase (CK-B*), fumarase (FH*), isocitrate
dehydrogenase (ICDH-S*), and lactate dehydrogenase (LDH-B*), were unique in C.
Agios Pharmaceuticals, the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases, announced today a recent publication that highlights the discovery of the first potent inhibitors of mutant isocitrate
dehydrogenase (IDH) that lower tumor 2-HG in vivo.