isocitrate


Also found in: Encyclopedia.

i·so·ci·trate

(ī'sō-sit'rāt),
(ī-sīt'rāt), A salt or ester of isocitric acid.

isocitrate

/iso·ci·trate/ (i″so-sĭ´trāt) a salt of isocitric acid.

i·so·ci·trate

(ī'sō-sit'rāt)
A salt or ester of isocitric acid.
References in periodicals archive ?
The eight enzymatic systems analyzed were Aspartate Amino Transferase (AAT), Acid Phosphatase (ACP), Glucose Dehydrogenase (GDH), Glucose 6-Phosphate Isomerase (GPI), Isocitrate Dehydrogenase (IDH), Malate Dehydrogenase (MDH), Malic Enzyme (ME) and Phosphoglucomutase (PGM)
The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase (ICH) a-ketoglutarate dehydrogenase (KDH) succinate dehydrogenase (SH) malate dehydrogenase (MDH) NADPH dehydrogenase and cytochrome C oxidase were significantly decreased in CCl4- hepatotoxic rats and administration of corosolic acid brought back these parameters towards normal.
The product is used to treat patients with acute myelogenous leukemia that harbour an isocitrate dehydrogenase-2 (IDH2) mutation.
Of respiratory enzymes, lactate dehydrogenase remained unaffected in both populations but isocitrate dehydrogenase (ICDH) activity showed significant increase (87%) in resistant and decrease (81%) in susceptible populations.
A notable example is the enzyme isocitrate dehydrogenase.
Activities of NADP-ICDH and NADH-GDH in tomato leaves: In higher plants, NADP-dependent isocitrate dehydrogenase (NADPH-ICDH) provides C-skeletons in the form of 2-oxoglutarate, which requires for both the activities of GS/GOGAT cycle enzymes and/or the activity of NADH-GDH to synthesize glutamate.
1] isocitrate dehydrogenase), except 50 mM Tris/HCl buffer (pH 7.
A similar mechanism of inhibition has been reported for other enzymes inhibited by Cd, such as Oggl and nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase (Kil et al.
The partial sequences for the mitochondrial enzymes of the TCA cycle such as aconitase (AT) and isocitrate dehydrogenase (ICD) were also isolated.
net/cgi-bin/mlst7/ index) uses PCR primers to amplify internal segments of 7 specific housekeeping genes (aspartate aminotransferase [aspC], caseinolytic protease [clpX], acyl-CoA synthetase [fadD], isocitrate dehydrogenase [icdA], lysine permease [lysP], malate dehydrogenase [mdh] and uidA), which are purified and sequenced.
Four of 16 allozyme loci, creatine kinase (CK-B*), fumarase (FH*), isocitrate dehydrogenase (ICDH-S*), and lactate dehydrogenase (LDH-B*), were unique in C.
Agios Pharmaceuticals, the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases, announced today a recent publication that highlights the discovery of the first potent inhibitors of mutant isocitrate dehydrogenase (IDH) that lower tumor 2-HG in vivo.