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irinotecan

   Also found in: Acronyms, Wikipedia 0.01 sec.
irinotecan /iri·no·te·can/ (i″rĭ-no-te´kan) a DNA topoisomerase inhibitor used as the hydrochloride salt as an antineoplastic in the treatment of colorectal carcinoma.
irinotecan,
an antineoplastic hormone.
indication It is used to treat metastatic carcinoma of the colon or rectum.
contraindications Pregnancy and known hypersensitivity to this drug prohibit its use.
adverse effects Life-threatening effects include leukopenia, anemia, and neutropenia. Other adverse effects include fever, headache, chills, dizziness, diarrhea, nausea, vomiting, anorexia, constipation, cramps, flatus, stomatitis, dyspepsia, site irritation, rash, sweating, dyspnea, increased cough, rhinitis, vasodilation, edema, asthenia, and weight loss.


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Standard first-line treatments including fluorouracil (5-FU) with leucovorin (LV) and irinotecan or oxaliplatin, alone or combined with bevacizumab, have resulted in a median overall survival (mOS) greater than 20 months [3-9].
Anti-epidermal growth factor receptor monoclonal antibodies ... by Ruiz-Echarri, Manuel; Ramos, Francisco Javier; Macarulla, Teresa; Capdevila, Jaume; Elez, Elena; Tab / Advances in Gastrointestinal Cancer
Therefore, AHCC is safe and unlikely to result in increased toxicity when used in combination with commonly used chemotherapeutic agents such as Cyclophosphamide, Ifosfamide, Paclitaxel, Docetaxel, Irinotecan, Vincristine, interferon and Imatinib.
Study supports safety of AHCC in combination with chemotherapy by Nutraceuticals World
ScinoPharm's proprietary process, circumventing the previous photo chemistry, leads to an enhanced efficiency in the synthesis of SN-38, and hence improves also the cost-efficiency of manufacturing irinotecan as a whole.
Patent granted to ScinoPharm for production of irinotecan intermediate by BIOTECH Patent News
 
 
 
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