ion channels


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ion channels

Protein ports in cell membranes that are specific for the passage of sodium, potassium, calcium and chloride ions in solution. Changes in the protein configuration, under the influence of various hormone molecule attachment, intracellular ion or other chemical concentration, or electrical potential, cause ion channels to open or close as required. Many diseases result from disordered function of ion channels.
References in periodicals archive ?
Used in pre-clinical pharmaceutical development, the Cellaxess(R)HT System enables high throughput RNAi screening and the Dynaflow(R)HT System greatly advances ion channel drug discovery.
The system comes with the newly developed DF-8 Pro II Chip successfully beta-tested for conducting GLP hERG studies by Swiss ion channel CRO bSys GmbH.
Those are just some of the reasons why scientists want to better understand how ion channels work.
Although there's no direct evidence yet that menthol binds to the newfound ion channel, both research groups suggest that the chemical produces a cooling sensation by increasing the temperature threshold at which the receptor activates.
The platform enables researchers and pharmaceutical companies to target ion channels that are clinically important but historically have been difficult to screen.
Table 2: World Historic Review for Ion Channel Modulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America, and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2004 through 2009 (includes corresponding Graph/Chart) II-37 Table 3: World 15-Year Perspective for Ion Channel Modulators by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America, and Rest of World Markets for Years 2004, 2012, and 2018 (includes corresponding Graph/Chart) II-38
Brown is a recognized expert in the field of molecular physiology and pharmacology of ion channels and their clinical relevance for cardiac drug safety.
PRODUCT OVERVIEW II-7Ion Channel Modulators: An Introduction II-7Biological Significance of Ion Channels II-7Ion Channel Modulators as an Option for Treating Diseases II-7Types of Ion Channels II-8Voltage-Gated Ion Channels II-8Extracellular Ligand-gated Ion Channels II-9Intracellular Ligand-gated Ion Channels II-11
Certain ion channels keep the heart beating rhythmically.
the leader in scalable, high performance cell loading systems, will host case study discussions with industry experts demonstrating how the MaxCyte[R] STX[TM] Scalable Transfection System improves transfection of cells with ion channels for cell-based assays for drug discovery screening.