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Ritonavir-boosted Invirase in combination with other antiretroviral medicines is indicated for the treatment of HIV-infected adults, EMA added.
Unfortunately, a major drawback of Invirase was its limited bioavailability due to incomplete absorption and extensive first-pass metabolism.
AHF believes there is simply no justification for the high prices of drugs such as Kaletra, Aptivus, Reyataz, Invirase and Fuzeon.
The only exception: Invirase (saquinavir), a protease inhibitor taken by some people with HIV, is so poorly absorbed that using grapefruit juice to boost its effect can only help.
developers of both drugs under the respective brand names of Invirase and Hivid, says that in addition to living longer patients who took the combination experienced fewer life-threatening health problems than patients who received either drug alone.
It is almost impossible to pick up a gay magazine these days without seeing Hoffmann-La Roche's four-page ads for Invirase, one of a new class of antiviral drugs known as protease inhibitors.
Some other drugs such as Epivir, Epzicom, Trizivir, Ziagen, Invirase and Lexiva are going off patent in 2009 and 2010.
5 (intermediate 0 (low penetration) penetration) Nucleoside or nucleotide reverse transcriptase inhibitors Retrovir (zidovudine) Emtriva Videx (didanosine) (emtricitabine) Ziagen (abacavir) Epivir (lamivudine) Viread (tenofovir) Zerit (stavudine) Nonnucleoside reverse transcriptase inhibitors Viramune (nevirapine) Sustiva (efavirenz) Intelence (etravirine) * Protease inhibitors Crixivan (indinavir) Reyataz (atazanavir) Aptivus (tipranavir) + (+ RTV) RTV Kaletra (lopinavir + Reyataz + RTV Invirase (saquinavir) RTV) + RTV Agenerase[dagger] Prezista (darunavir) + Norvir (ritonavir) (amprenavir) + RTV RTV Viracept (nelfinavir) Entry inhibitors Selzentry Fuzeon (enfuvirtide) (maraviroc) * Integrase inhibitors Isentress (raltegravir) * RTV = ritonavir (Norvir).
Interestingly, Hoffman-LaRoche is now moving back to the original Invirase formulation of saquinavir (with a new 500-mg tablet) because it is better tolerated than the Fortovase version when the drug is combined with ritonavir.
A combination treatment consisting of three antiviral agents - the HIV-protease inhibitor Invirase, Hivid and AZT - may be a better option for HIV-infected persons than dual therapy with AZT plus either of the other drugs, according to a study in today's New England Journal of Medicine.
s Invirase (saquinavir) as the first of a new type of AIDS medication that works when used with nucleoside analogues, the conventional class of AIDS therapies.
Patients taking either boosted or unboosted Invirase (saquinavir, hard gel capsules) or Fortavase (saquinavir, soft-gel capsules) should not take rifampin (brand names include Rifadin and Rimactane), a med used to treat bacterial infections like tuberculosis.