intrinsic pathway


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Related to intrinsic pathway: Extrinsic pathway

intrinsic pathway

Hematology An arm of the coagulation cascade, initiated by negatively charged surfaces–contact factors–eg, sulfatide micelles, kaolin which bind factor XII and HMW kininogen–HMWK; HMWK binds prekallikrein and factor XI, activating the latter; XIa then activates IX which in turn activates factor X, initiating the common pathway. See Common pathway, Extrinsic pathway.

Intrinsic pathway

One of three pathways in the coagulation cascade.
References in periodicals archive ?
A correction of the PTT in the mixture identifies a deficiency of one or more factors of the intrinsic pathway.
Some recommended procedures for acquiring samples for coagulation analysis, especially those involving the measurement of D-dimer and fibrinogen by the Clauss method, mandate that the first sample be discarded because tissue thromboplastin released by the trauma of venipuncture could interfere with coagulation assays by activating intrinsic pathway (2).
TTP889 is the only known selective small molecule inhibitor of Factor IX/IXA, a key enzyme of the intrinsic pathway of the blood coagulation system.
Bcl-2 protein is an anti-apoptosis member of the Bcl-2 family which consists of both pro-apoptotic and anti-apoptotic members that are key regulators of the intrinsic pathway of apoptosis (Marzo and Naval, 2008).
These data in combination with those of others (2) suggest that in erythroid differentiation, an intrinsic pathway is activated with apoptotic features, although other features of apoptosis, such as differential binding of Annexin V, are lacking.
In general terms, apoptotic pathways can be sub-divided into two categories, the extrinsic pathway and the intrinsic pathway (Wajant, 2002).