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intrinsic pathway

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Intrinsic pathway
One of three pathways in the coagulation cascade.

intrinsic pathway
Hematology An arm of the coagulation cascade, initiated by negatively charged surfaces–contact factors–eg, sulfatide micelles, kaolin which bind factor XII and HMW kininogen–HMWK; HMWK binds prekallikrein and factor XI, activating the latter; XIa then activates IX which in turn activates factor X, initiating the common pathway. See Common pathway, Extrinsic pathway.


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DIAGNOSIS Bleeding diathesis with hemophilic arthropathy DISCUSSION There are 2 major types of hemophilia: hemophilia A (classic hemophilia), which is a functional deficiency of Factor VIII of the intrinsic pathway of coagulation; and hemophilia B (Christmas disease), which is a functional deficiency of Factor IX of the extrinsic pathway of coagulation.
There are two ways to do this: a so-called intrinsic pathway and a so-called extrinsic pathway.
 
 
 
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