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intrinsic pathway |
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Intrinsic pathway One of three pathways in the coagulation cascade. Mentioned in: Partial Thromboplastin Time intrinsic pathway Hematology An arm of the coagulation cascade, initiated by negatively charged surfaces–contact factors–eg, sulfatide micelles, kaolin which bind factor XII and HMW kininogen–HMWK; HMWK binds prekallikrein
and factor XI, activating the latter; XIa then activates IX which in turn activates factor X, initiating the common pathway. See Common pathway, Extrinsic pathway. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases. This glycoprotein seems to inhibit the activation of the contact phase system of the intrinsic pathway of blood coagulation (10). TTP889 is the only known selective small molecule inhibitor of Factor IX/IXA, a key enzyme of the intrinsic pathway of the blood coagulation system. |
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