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familial adenomatous polyposis |
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familial adenomatous polyposis (FAD), an inherited disorder characterized by the development of myriad polyps in the colon, beginning in late adolescence or early adulthood. Untreated, the condition nearly always leads to colon cancer. See also adenomatous polyposis coli. familial adenomatous polyposis Familial polyposis An AD condition affecting ±50,000–US, characterized by progressive development of hundreds of adenomatous colorectal polyps; progression to cancer Molecular pathology APC
gene on chromosome 5q21 is mutated in FAP, which may also be mutated in sporadic colorectal tumors Diagnosis Allele-specific expression assay, in vitro synthesized protein assay Treatment Sulindac How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Over the next 12 months, the patient's condition improved significantly, with marked regression of the intestinal polyposis, resolution of the diarrhea and hypoalbuminemia, weight gain, regrowth of body hair, and normalization of the nail and skin findings. |
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