intervertebral discs


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intervertebral discs

the soft pads between the bodies of the vertebrae which make up the spinal column. Each disc has an inner spongy gelatinous substance (nucleus pulposus) surrounded by a protective ring of fibrocartilage (annulus fibrosus). The discs contribute to flexibility of the spine and act as shock absorbers. prolapsed intervertebral disc syn slipped disc protrusion of the nucleus pulposus through its fibrous covering into the spinal canal, due to degenerative changes, heavy lifting or injury in sport. Can press on the spinal cord or on the nerve roots, leading to pain, numbness, paraesthesia or even paralysis. Most common in the lumbar region, causing sciatica if the roots of the sciatic nerve are compressed. Diagnosis is clinical with MRI scanning to confirm. Treatment is initially rest with appropriate analgesia, then a programme of core muscle strengthening to prevent recurrence. Persistent neurological symptoms and signs require investigation and, rarely, surgical treatment with minimally invasive microdiscectomy. In sport the commonest disc injuries are in the lumbar and cervical regions, the latter typically in rugby (scrum collapse or direct injury in a tackle), in judo or in a fall from a height as in trampolining or gymnastics. These injuries highlight the need for adequately trained and experienced medical back-up.
References in periodicals archive ?
Intervertebral discs were isolated and Western blotting was applied to detect protein levels in intervertebral discs [Table 3] and [Figure 2].
Vascularization and morphological changes of the endplate after axial compression and distraction of the intervertebral disc.
Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety and Preliminary Results," Tissue Engineering Part C: Methods, 2017; DOI: 10.
Zhao, "Oxidative stress participates in age-related changes in rat lumbar intervertebral discs," Archives of Gerontology and Geriatrics, vol.
Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc.
Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs.
Anterior microdiscectomy C5-C6 was performed with removal of the intervertebral disc consisting of the nucleus pulposus and annulus fibrosus with caudal extension, placement of interbody cage and titanium plate.
5 Intervertebral disc disease is a major epide- miological problem as 50 70% of adults experience at least one episode of the low back pain in their life time.
This 'unit' comprises the superior half of the inferior vertebrae, plus the intervertebral disc, plus the inferior half of the superior vertebrae.
Contributors from the research side--materials science and engineering--from the application side--orthopedic surgery and pathology--and from intermediate areas--tissue engineering and biomechanics--consider fundamentals of biomaterials for spinal surgery, spinal fusion and intervertebral discs, vertebroplasty and scoliosis surgery, and regenerative medicine in the spine.
Mesoblast Limited (ASX: MSB) of Melbourne, Australia, announced that its phase 2 clinical trial investigating the use of allogeneic, or off-the-shelf, Mesenchymal Precursor Cells (MPCs) for non-surgical restoration of degenerated intervertebral discs and treatment of low back pain has enrolled half of the total expected patients.

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