intermediate filaments

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in·ter·me·di·ate fil·a·ments

a class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 9-11 nm in thickness and make up part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules.

intermediate filaments

part of the cell cytoskeleton, forming a network around the nucleus, extending to the cell periphery and crossing the cell membrane to form desmosomes


1. between; intervening; resembling, in part, each of two extremes.
2. a substance formed in a chemical process that is essential to formation of the end-product of the process.

intermediate cell mass
intermediate filaments
intracellular protein fibers which are part of the cytoskeleton in eukaryotic cells.
intermediate host
especially in parasitology, a host in which the parasite undergoes a stage, usually the larval or nonsexual stage, in its development. The host may be an insect vector which also acts as the transmitting medium, or another insect or animal species which is a passive enhancer, the infection being spread by other means.
intermediate junction
see zonula adherens.
intermediate mesoderm
mesoderm located just lateral to the somites, uniting the paraxial and lateral plate mesoderm.
intermediate sheep footrot
less underrunning of horn and less likelihood of resulting in chronic lesions than in virulent footrot.
References in periodicals archive ?
Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene.
Figure 13: infectious muscle, 4 hour after injection, Desmin intermediate filament (arrowhead) within the Myocytes that surrounding by inflammatory cells (arrow) is seen.
The role of intermediate filaments in this process may be in binding proteins that participate in transport processes and/or by contributing to the organization of subcellular organelles.
Coiled coil trigger motifs in the 1B and 2B rod domain segments are required for the stability of keratin intermediate filaments.
2001): "Lactation affects expression of intermediate filaments in human breast epithelium", en Differentiation 67: 41-49.
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments.
Deregulation of intermediate filament protein phosphorylation leads to pathogenesis: a review.
In the cytoplasm of dedifferentiating peritoneal cells, bundles of intermediate filament split into short fragments.
The tumors from patient 1 (Figure 3, A and B) and patient 2 (Figure 3, C and D) were composed of bipolar spindle cells with occasional intermediate filaments, no definitive secretory granules, and no significant accumulation of mitochondria.
The cells displayed numerous desmosomal connections, complex interactions of the lateral membranes, and abundant intermediate filaments within the cytoplasm.
The parasites locate freely within the cytoplasm of the host cell, although each colony appears to be confined to specific domains by the accumulation of intermediate filaments that surround the parasites.
The pathophysiology of vascular damage in maternal decidual vasculopathy is unknown, but the 2 key findings in the involved vessels in this lesion are well described: (1) atherosis appears to be histiocytic phagocytosis of damaged endothelial cells of the spiral arteries, and (2) the dense pink fibrinoid necrosis may be some amalgam of the coagulation cascade proteins and intermediate filaments.

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