intermediate filament

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intermediate filament

Any of a group of protein filaments that are a component of the cytoskeleton in animal cells, are composed of a variety of proteins such as lamins and keratins, and provide structural support for the cytoplasm and nucleus. Intermediate filaments are intermediate in diameter between microfilaments and microtubules, the other components of the cytoskeleton.

intermediate filament

Abbreviation: IF
Slender proteins found in all eukaryotic cells, measuring about 8 to 12 nm in diameter. Intermediate filaments are composed of proteins including desmin, keratins, lamins, and vimentin and together with microtubules and microfilaments form the cytoskeleton. Some malignant cells can be identified by the specific proteins in their intermediate filaments.
See also: filament


a delicate fiber or thread.

beard filament
structures of the beard of the male turkey are neither hairs nor feathers but have some of the characteristics of both.
filament control
in an x-ray machine this controls the filament current in the x-ray tube. The size of the current and its duration are controlled in this way.
filament current
in an x-ray machine the strength of the current to the filament is varied by the use of a filament or stepdown transformer.
filament focal spot size
the focal spot of the x-ray beam should be as small as possible to give maximum sharpness and clarity. Its size is determined by the size of the filament opposite that generates the beam, the anode angle and other factors.
intermediate filament
non-contractile elements in the supportive structure of cytoplasm.
References in periodicals archive ?
The [alpha]-helical rod domain is critical for the assembly of intermediate filament proteins into filaments and contains all the information necessary for assembly, while the variant end domains play accessory roles in filament assembly and interaction with other proteins and cell structures.
Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.
Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins.
BORISY: A second question is, if intermediate filament proteins are the major binding partner for plectins, how do you explain the phenotype of the vimentin knockout mouse reported in the literature?
2,3] In addition, they commonly coexpress other intermediate filament proteins such as glial filament acidic protein.
Expression of four different types of intermediate filament proteins within the same cell type.
1981) known to bind to most of the defined major intermediate filament proteins.
Cytokeratins are well-described intermediate filament proteins of both normal epithelia and epithelial tumors.

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