intermediate filament

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intermediate filament

Any of a group of protein filaments that are a component of the cytoskeleton in animal cells, are composed of a variety of proteins such as lamins and keratins, and provide structural support for the cytoplasm and nucleus. Intermediate filaments are intermediate in diameter between microfilaments and microtubules, the other components of the cytoskeleton.

intermediate filament

Abbreviation: IF
Slender proteins found in all eukaryotic cells, measuring about 8 to 12 nm in diameter. Intermediate filaments are composed of proteins including desmin, keratins, lamins, and vimentin and together with microtubules and microfilaments form the cytoskeleton. Some malignant cells can be identified by the specific proteins in their intermediate filaments.
See also: filament


a delicate fiber or thread.

beard filament
structures of the beard of the male turkey are neither hairs nor feathers but have some of the characteristics of both.
filament control
in an x-ray machine this controls the filament current in the x-ray tube. The size of the current and its duration are controlled in this way.
filament current
in an x-ray machine the strength of the current to the filament is varied by the use of a filament or stepdown transformer.
filament focal spot size
the focal spot of the x-ray beam should be as small as possible to give maximum sharpness and clarity. Its size is determined by the size of the filament opposite that generates the beam, the anode angle and other factors.
intermediate filament
non-contractile elements in the supportive structure of cytoplasm.
References in periodicals archive ?
Intermediate filaments are dynamic and motile elements of cellular architecture.
Figure 14: infectious muscle 24 hours after injection, Desmin intermediate filament (arrowhead) within the Myocytes that surrounding by inflammatory cells (arrow) is seen.
Our previous observations on the co-localization of GSLs with intermediate filaments led us to analyze the role of the filaments in the biosynthesis and intracellular transport of GSLs.
They help in attachment of keratin intermediate filament cytoskeleton to cell surface.
2009): "Self-organization of keratin intermediate filaments into cross-linked networks", en The Journal of Cell Biology 186(3): 409-421.
Intermediate filaments and vesicular membrane traffic: the odd couple's first dance?
Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis.
Lamins are cytoskeletal proteins belonging to the family of intermediate filaments.
The hyperphosphorylation of proteins have been attributed to the destruction of intermediate filaments (IFs) (12,13).
1,2,4,5,7-22) As part of the intermediate filaments family, different CKs were shown to be expressed in both benign and malignant mesenchymal tissue specimens.
The viscoelastic properties of networks formed by Factin, microtubules, and various intermediate filament types (e.
13) Desmin, the intermediate filament protein of skeletal muscle fibers, cardiac myocytes, and certain smooth muscle cells, is a part of the cytoskeletal domain linking Z-bands with the plasmalemma and the nucleus.

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