intermediate filament

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intermediate filament

Any of a group of protein filaments that are a component of the cytoskeleton in animal cells, are composed of a variety of proteins such as lamins and keratins, and provide structural support for the cytoplasm and nucleus. Intermediate filaments are intermediate in diameter between microfilaments and microtubules, the other components of the cytoskeleton.

intermediate filament

Abbreviation: IF
Slender proteins found in all eukaryotic cells, measuring about 8 to 12 nm in diameter. Intermediate filaments are composed of proteins including desmin, keratins, lamins, and vimentin and together with microtubules and microfilaments form the cytoskeleton. Some malignant cells can be identified by the specific proteins in their intermediate filaments.
See also: filament


a delicate fiber or thread.

beard filament
structures of the beard of the male turkey are neither hairs nor feathers but have some of the characteristics of both.
filament control
in an x-ray machine this controls the filament current in the x-ray tube. The size of the current and its duration are controlled in this way.
filament current
in an x-ray machine the strength of the current to the filament is varied by the use of a filament or stepdown transformer.
filament focal spot size
the focal spot of the x-ray beam should be as small as possible to give maximum sharpness and clarity. Its size is determined by the size of the filament opposite that generates the beam, the anode angle and other factors.
intermediate filament
non-contractile elements in the supportive structure of cytoplasm.
References in periodicals archive ?
Intermediate filaments and vesicular membrane traffic: the odd couple's first dance?
Although not essential for diagnosis, negative myogenic markers and electron microscopic confirmation of cytoplasmic intermediate filaments in swirls or whorls provide additional support for this diagnosis.
Immunocytoechemical analysis of Ewing's tumors: patterns of expression of intermediate filaments and desmosomal proteins indicate cell type heterogeneity and pluripotential differentiation.
Common findings were dilated stacks of rough endoplasmic reticulum, polyribosomes, randomly distributed intermediate filaments, and rare collagen secretion granules (Fig 5).
It's not yet clear whether crescentin strands gave rise to the intermediate filaments in animal cells or whether those filaments evolved independently, says Jacobs-Wagner.
The neurofilament proteins are found in neurons and assemble to form intermediate filaments that regulate axon growth, axoplasmic transport, and axon caliber (Capano et al.
Many of the tumor cells had perinuclear bundles of intermediate filaments.
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
Axonal transport and neurotransmitter release, for example, are now known to occur by mechanisms that are related to those of membrane trafficking and secretion used by all eukaryotic cells, and the neurofilaments whose unusual staining properties allowed neuroanatomists to trace axonal tracts are now recognized as part of a larger family of intermediate filaments found in many cell types.

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