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interleukin-12

   Also found in: Encyclopedia, Wikipedia 0.02 sec.
interleukin-12 (IL-12),
a protein produced by activated T cells that stimulates cell-mediated killing by natural killer cells and lymphocytes. It promotes the maturation of cytotoxic T cells.


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Furthermore, a Major Histocompatibility Complex (MHC)-class-I-restricted T cell activation ELISPOT assay showed elevated interferon- [gamma], interleukin-2, and interleukin-12 production in HA/SHIV 89.
In test-tube studies, the researchers found that this production of interleukin-12 can also arouse the self-reactive immune cells that cause autoimmune problems.
In this Phase I open-label study, plasmid DNA encoding a cytokine, interleukin-12 (IL-12), is delivered directly to tumors in patients with malignant melanoma through electroporation using the MedPulser(R) DNA Electroporation System.
 
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