IL17A

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IL17A

A gene on chromosome 6p12 that encodes interleukin-17A, a proinflammatory cytokine produced by activated T cells which regulates NF-kappaB and mitogen-activated protein kinases. It upregulates IL6 and cyclooxygenase-2 and increases nitric oxide production.

Molecular pathology
IL17A is overexpressed in rheumatoid arthritis, psoriasis and multiple sclerosis.
References in periodicals archive ?
Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis.
Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2.
Among those who received the higher dose, the proportion of pro-inflammatory interleukin 17 (IL-17) producing cells decreased, suggesting a reduction in disease severity.
TH17 cells, which are responsible for inflammation and tissue injury in autoimmune disease, are developmentally distinct from TH-1 and TH-2 cells, and are capable of producing interleukin 17 (IL-17), a pro-inflammatory cytokine.
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
Interleukin 17 (IL17) is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma [57].
9 May 2014 - A study, published in the European Journal of Medical Research, has demonstrated that evaluation of interleukin 17 (IL-17) levels may be a diagnostic and prognostic marker for lung cancer patients with malignant pleural effusion (MPE).
In both cases, the immune cells produced fewer inflammatory molecules, particularly one called interleukin 17, or IL-17, which is strongly associated with MS and very harmful to nerve cells and their insulating covers.
The immune system protein Interleukin 17 is one of the critical signals involved in the progression of psoriasis.
Saleh bin Zaid Al-Mohsen overseeing the program and the director of Prince Naif Center for Health Research have succeeded in discovering the most common cause of inflammatory innate in children, resulting from the disruption of the immune system in the composite named Interleukin 17 (IL-17).
The name Th17 refers to their release of a protein called Interleukin 17 (or IL-17).
Interleukin 17 (IL-17) is secreted by activated T-cells (Th17 cells), and has an important function as an inflammatory mediator * Th17 cells are implied in the pathogenesis of a number of human autoimmune disease conditions and their animal models, including multiple sclerosis and experimental autoimmune encephalomyelitis * Th17 cells strongly accumulate in the inflamed central nervous system (CNS) during the autoimmune reaction * Genetic deficiency in IL-17 or pharmacological neutralization of IL-17 leads to amelioration of clinical disease symptoms, but not to their complete abrogation * Short-term systemic presence of microbial stimuli can lead to priming of CNS-autoantigen-specific Th17 cells and subsequent clinical autoimmune disease