IL13

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IL13

A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.

Molecular pathology
IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms.
References in periodicals archive ?
In the new study, Chawla s team determined that both interleukin 4 and interleukin 13 recruit macrophages to fat and that the production of molecules called catecholamines by the macrophages causes the browning of white fat.
In fact, another study published simultaneously in Cell by researchers from the Dana-Farber Cancer Institute and Harvard Medical School reports the identification of a hormone, produced in fat tissue after cold exposure, that activates interleukin 4 and interleukin 13 to drive fat burning.
Interleukin 13 appears to be a potential central mediator of fibrosis in a variety of models and is found upstream of TGF-[beta]1, a well-known mediator of pulmonary fibrosis.
Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung.
Currently, Targepeutics' three pharmaceutical platforms are Genetically Engineered Interleukin 13 (IL- 13), Immunotherapy (applications in cancer and asthma), and Anti-tumor Progression (targeting growth and ability of solid tumors to create new blood vessels).
Interleukin 13, however, was always undetectable in serum.
The role of interleukin 13 in classical Hodgkin lymphoma.
IL-13ra1 is a receptor chain mediating the action of interleukin 13 (IL-13) and interleukin 4 (IL-4), two cytokines investigated for their role as mediators of allergic reactions and for their anti-inflammatory action.
The targeting component consists of interleukin 13 (IL13) an immune regulatory cytokine (normally made by cells of the immune system).
Uvidem is a Cell Drug containing dendritic cells which have been generated using IDM's patented technology in presence of Interleukin 13.