IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: associations with presenting features, serum interleukin 10 levels, and clinical outcome.
The license agreement provides Avigen with exclusive rights to pending patent applications owned by the University of Colorado covering the use of anti-inflammatory cytokines, including interleukin 10 (IL-10), for the treatment of chronic pain being developed in the multi-disciplinary Watkins/Maier laboratory in the Department of Psychology and Center for Neuroscience.
We feel interleukin 10 (IL-10) might be produced by the tumor itself before it is clinically evident," said Dr.
All three drugs significantly increased interleukin 10 (IL-10) and suppressed the IFN-[gamma]/IL-10 ratio (J.
A replicon encoding an anti-inflammatory protein, such as interleukin 10, might limit such damage, Morrow says.
Roland Veltkamp, senior physician at the Neurology Clinic of Heidelberg University Hospital, points out that the regulator cytokine interleukin 10 (IL 10) plays an important role in this protection, and that this work offers a new approach to stroke therapy.
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
announced today that it has exclusively licensed rights to the treatment of chronic pain using anti-inflammatory cytokines, including interleukin 10 (IL-10), from the University of Colorado.
We investigated the potential relationship between breast cancer and polymorphisms of the interleukin 10 (IL-10) and tumor necrosis factor-[alpha] (TNF-[alpha]) genes.
Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.
In this study, the improvements in disease-related parameters resulting from IMO-3100 treatment were associated with suppression of interleukin 6 (IL-6) and complement C3 and with induction of interleukin 10 (IL-10).
Elias' team also found that patients receiving DiaPep277 produced more interleukin 10 and interleukin 13, hormone-like cytokine proteins that inhibit inflammation.