IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
The report provides comprehensive information on the Interleukin 10 (Cytokine Synthesis Inhibitory Factor or CISF or IL10) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: associations with presenting features, serum interleukin 10 levels, and clinical outcome.
Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus.
After testing the hypothesis on mice, researchers found that at six-weeks-post infection, the animals exhibited increased expression of three cytokines - interleukin 4, interleukin 10 and transforming growth factor-alpha mRNA.
The Th 2 cytokine interleukin 10 is immunoinhibitory and it is capable of stimulating tumor growth (6).
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.
Endogenous interleukin 10 prevent apoptosis in macrophages during Salmonella infection.
High interleukin 12 and low interleukin 10 production after in vitro stimulation detected in sepsis survivors.
Alameda, CA) has exclusively licensed rights to the treatment of chronic pain using anti- inflammatory cytokines, including interleukin 10 (IL-10), from the University of Colorado (Boulder, CO).
In HIV-infected patients, serum levels of interleukin 10 increase markedly just before B-cell lymphoma is clinically recognized, Elizabeth Crabb Breen, Ph.
Antidepressants enhance production of interleukin 10 and significantly suppress the ratio of interferon gamma to interleukin 10, reported Marta Kubera, Ph.