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interferon gamma

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interferon gamma,
a small, species-specific glycoprotein produced by mitogen-stimulated T cells. It possesses antiviral activity and plays a central role in the immunoregulatory processes.

interferon (in´trfir´on),
n a small class of glycoproteins capable of exerting antiviral activity in homologous cells through metabolic processes involving synthesis of RNA.
interferon alpha,
n a type formed by leukocytes in response to viral infection or by stimulation with double-stranded RNA. These protein products are used as antineoplastic agents. Specifically used as an antineoplastic agent for the treatment of Kaposi's sarcoma in AIDS patients. See also interferon alfa-2a.
interferon alfa-2a/interferon alfa-2b/interferon alfa-n1/interferon alfa-n3,
n brand names: Roferon-A, Intron-A, Alferon N;
drug class: biologic response modifier;
action: antiviral action inhibits viral replication by reprogramming virus; antitumor action suppresses cell proliferation; immunomodulating action phagacytizes target cells;
uses: hairy-cell leukemia in persons older than 18 years, metastatic melanoma, AIDS, Kaposi's sarcoma, bladder carcinoma, lymphomas, malignant myeloma, mycosis fungoides.
interferon beta,
n a type formed by fibroblasts by stimulation similar to the alpha form.
interferon gamma,
n a type formed by lymphocytes in response to mitogenic stimulation. See also interferon gamma-1b.
interferon gamma-1b,
n brand name: Actimmune;
drug class: biologic response modifier;
action: species-specific protein synthesized in response to viruses, enhances antibody-dependent cellular cytotoxicity, enhances natural killer cell activity;
uses: serious infections associated with chronic granulomatous disease.

interferon gamma
IFN-γ A 21-25 kD glycoprotein lymphokine encoded on chromosome 12q and produced by activated T and NK cells; IFN-γ is antiviral, regulates class II MHC antigen expression, Fc receptors and immunoglobulin production and class switching, activates monocyte cytotoxicity and enhances NK cell activity; IFN-γ is ↓ in IgA deficiency, lymphoma, CLL, infections–eg, CMV, EBV, rubella, lepromatous leprosy, TB, SLE, rheumatoid arthritis, sickle cell anemia, post-transplantation Indications Recombinant IFN-γ is used to treat condylomata acuminata, CLL, Hodgkin's disease, mycosis fungoides, rheumatoid arthritis, and possibly leprosy, TB, nontuberculous mycobacterial infections, toxoplasmosis, chronic granulomatous disease–to prevent infections; IFN-γ suppresses collagen synthesis by fibroblasts, ↓ the size of keloids, causing a local ↑ in inflammatory cells and mucin production, and may be of use in controlling abnormal fibrosing conditions Side effects Acute renal failure, rash, headache, chills


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In May 2008, Exir began producing hepatitis C treatment interferon gamma under the brand name Gamma Immunex.
Other topics will include new TB diagnostics including the use of molecular tests and interferon gamma release assays, global laboratoryimplications, and laboratory integration into TB control.
We did a small clinical observation on chronic fatigue and breast cancer patients looking at their interferon gamma levels (part of the body's mechanism to fight disease) and found that in all cases their levels went up when they had Simba.
 
 
 
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