Insulin lispro recombinant

insulin /in·su·lin/ (in´sdbobr-lin)

1. a protein hormone formed from proinsulin in the beta cells of the pancreatic islets of Langerhans. The major fuel-regulating hormone, it is secreted into the blood in response to a rise in concentration of blood glucose or amino acids. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis.

Insulin. The precursor proinsulin is cleaved internally at two sides (arrows) to yield insulin and C peptide.

2. a preparation of insulin, either of porcine or bovine origin or a recombinant form with sequence the same as or similar to that in humans, used in the treatment of diabetes mellitus; classified as rapid-acting, intermediate-acting, or long-acting on the basis of speed of onset and duration of activity.

3. regular insulin; a rapid-acting, unmodified form of insulin prepared from crystalline bovine or porcine insulin.

insulin aspart a rapid-acting analogue of human insulin created by recombinant DNA technology.

buffered insulin human insulin human buffered with phosphate; used particularly in continuous infusion pumps.

extended insulin zinc suspension a long-acting insulin consisting of porcine or human insulin in the form of large zinc-insulin crystals.

insulin glargine an analogue of human insulin produced by recombinant DNA technology, having a slow, steady release over 24 hours.

insulin human a protein corresponding to insulin elaborated in the human pancreas, derived from pork insulin by enzymatic action or produced synthetically by recombinant DNA techniques; sometimes used specifically to denote a rapid-acting regular insulin preparation of this protein.

isophane insulin suspension an intermediate-acting insulin consisting of porcine or human insulin reacted with zinc chloride and protamine sulfate.

Lente insulin insulin zinc suspension.

insulin lispro a rapid-acting analogue of human insulin synthesized by means of recombinant DNA technology.

NPH insulin isophane i. suspension.

prompt insulin zinc suspension a rapid-acting insulin consisting of porcine insulin with zinc chloride added to produce a suspension of amorphous insulin.

regular insulin insulin (3).

Semilente insulin prompt insulin zinc suspension.

Ultralente insulin extended insulin zinc suspension.

insulin zinc suspension an intermediate-acting insulin consisting of porcine or human insulin with a zinc salt added such that the solid phase of the suspension contains a 7:3 ratio of crystalline to amorphous insulin.

insulin lispro,

a pancreatic hormone.

indications It is used to treat ketoacidosis types I and II and types 1 and 2 diabetes mellitus.

contraindications Known hypersensitivity to this drug or to protamine prohibits its use.

adverse effects Anaphylaxis is a life-threatening effect of this drug. Other adverse effects include blurred vision, dry mouth, flushing, rash, urticaria, warmth, lipohypertrophy, swelling, redness, and rebound hyperglycemia (the Somogyi effect). Lipodystrophy and hypoglycemia are common side effects.

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