insertion mutation

insertion mutation

A mutation caused by the insertion into a DNA sequence of one or more nucleotides.

insertion mutation

a MUTATION in which one or more bases is inserted into DNA, often causing a FRAMESHIFT reading error during TRANSLATION.
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The results showed that both patients were a heterozygote for a novel insertion mutation c.
M2 PHARMA-October 31, 2017-Spectrum Pharmaceuticals Enrolls First Patient in Trial of Poziotinib in NSCLC Patients with Exon 20 Insertion Mutation in EGFR or HER2
Further analysis revealed that the insertion mutation caused a complete change of the first transmembrane domain, and deletion of the remaining six transmembrane domains (Figure 3).
Among 37 patients the wild type peak of 168 base pairs (bp) was seen in 34 patients (92%) while in addi-tion to wild type peaks another peak of 172 bp showing an insertion mutation in NPM1 gene was seen in 3 patients (8%) as shown in Fig.
The wild type peak is at ~198bp while a 4bp insertion mutation peak is at ~202bp.
A deletion or insertion mutation could also have drastic consequences, even if it occurred at a point distant to the functional domain, particularly if the insertion or deletion results in a change in the translation reading frame, which can destroy the protein.
These types, depending on the representation used are: Reciprocal exchange Mutation, Inversion mutation, Insertion mutation, Displacement mutation, Boundary mutation and Uniform random mutation.
This insertion mutation involving actin gene sequences is an unambiguous marker indicating that a novel gene family, and the complexity of function entailed in the interactions of its members, developed from a random event that occurred in an ancestor of apes and OWMs.
To date, eight platinum-refractory patients with EGFR exon 20 insertion mutation metastatic NSCLC have been enrolled in the clinical trial and treated with poziotinib at a dose of 16 mg PO daily.