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hair cell |
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One might reasonably anticipate that instillation of any topical cochleotoxic agent into the middle ear would primarily affect the inner hair cells responsible for ultrahigh-frequency hearing that are closest to the round window membrane portal of entry. Histopathologic studies have shown that outer hair cells are more sensitive to ototoxic injury than are inner hair cells. The hypothesis that subjective tinnitus is primarily caused by glutamate excitotoxicity at the synapses between inner hair cells and their afferents in the cochlea has been confirmed. |
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