influenza (redirected from Influenza w/ other respiratory manifestations)

Influenza 

Definition

Usually referred to as the flu or grippe, influenza is a highly infectious respiratory disease. The disease is caused by certain strains of the influenza virus. When the virus is inhaled, it attacks cells in the upper respiratory tract, causing typical flu symptoms such as fatigue, fever and chills, a hacking cough, and body aches. Influenza victims are also susceptible to potentially life-threatening secondary infections. Although the stomach or intestinal "flu" is commonly blamed for stomach upsets and diarrhea, the influenza virus rarely causes gastrointestinal symptoms. Such symptoms are most likely due to other organisms such as rotavirus, Salmonella, Shigella, or Escherichia coli.

Description

The flu is considerably more debilitating than the common cold. Influenza outbreaks occur suddenly, and infection spreads rapidly. The annual death toll attributable to influenza and its complications averages 20,000 in the United States alone. In the 1918–1919 Spanish flu pandemic, the death toll reached a staggering 20-40 million worldwide. Approximately 500,000 of these fatalities occurred in America.

Influenza outbreaks occur on a regular basis. The most serious outbreaks are pandemics, which affect millions of people worldwide and last for several months. The 1918–1919 influenza outbreak serves as the primary example of an influenza pandemic. Pandemics also occurred in 1957 and 1968 with the Asian flu and Hong Kong flu, respectively. The Asian flu was responsible for 70,000 deaths in the United States, while the Hong Kong flu killed 34,000.

Epidemics are widespread regional outbreaks that occur every two to three years and affect 5-10% of the population. The Russian flu in the winter of 1977 is an example of an epidemic. A regional epidemic is shorter lived than a pandemic, lasting only several weeks. Finally, there are smaller outbreaks each winter that are confined to specific locales.

The earliest existing descriptions of influenza were written nearly 2500 years ago by the ancient Greek physician Hippocrates. Historically, influenza was ascribed to a number of different agents, including "bad air" and several different bacteria. In fact, its name comes from the Italian word for "influence," because people in eighteenth-century Europe thought that the disease was caused by the influence of bad weather. It was not until 1933 that the causative agent was identified as a virus.

There are three types of influenza viruses, identified as A, B, and C. Influenza A can infect a range of animal species, including humans, pigs, horses, and birds, but only humans are infected by types B and C. Influenza A is responsible for most flu cases, while infection with types B and C virus are less common and cause a milder illness.

In the United States, 90% of all deaths from influenza occur among persons older than 65. Flu-related deaths have increased substantially in the United States since the 1970s, largely because of the aging of the American population. In addition, elderly persons are vulnerable because they are often reluctant to be vaccinated against flu.

A new concern regarding influenza is the possibility that hostile groups or governments could use the virus as an agent of bioterrorism. A report published in early 2003 noted that Type A influenza virus has a high potential for use as such an agent because of the virulence of the Type A strain that broke out in Hong Kong in 1997 and the development of laboratory methods for generating large quantities of the virus. The report recommended the stockpiling of present antiviral drugs and speeding up the development of new ones.

Causes and symptoms

Approximately one to four days after infection with the influenza virus, the victim is hit with an array of symptoms. "Hit" is an appropriate term, because symptoms are sudden, harsh, and unmistakable. Typical influenza symptoms include the abrupt onset of a headache, dry cough, and chills, rapidly followed by overall achiness and a fever that may run as high as 104°F (40°C). As the fever subsides, nasal congestion and a sore throat become noticeable. Flu victims feel extremely tired and weak and may not return to their normal energy levels for several days or even a couple of weeks.

Influenza complications usually arise from bacterial infections of the lower respiratory tract. Signs of a secondary respiratory infection often appear just as the victim seems to be recovering. These signs include high fever, intense chills, chest pains associated with breathing, and a productive cough with thick yellowish green sputum. If these symptoms appear, medical treatment is necessary. Other secondary infections, such as sinus or ear infections, may also require medical intervention. Heart and lung problems, and other chronic diseases, can be aggravated by influenza, which is a particular concern with elderly patients.

With children and teenagers, it is advisable to be alert for symptoms of Reye's syndrome, a rare, but serious complication. Symptoms of Reye's syndrome are nausea and vomiting, and more seriously, neurological problems such as confusion or delirium. The syndrome has been associated with the use of aspirin to relieve flu symptoms.

Diagnosis

Although there are specific tests to identify the flu virus strain from respiratory samples, doctors typically rely on a set of symptoms and the presence of influenza in the community for diagnosis. Specific tests are useful to determine the type of flu in the community, but they do little for individual treatment. Doctors may administer tests, such as throat cultures, to identify secondary infections.

Since 1999, however, seven rapid diagnostic tests for flu have become commercially available. These tests appear to be especially useful in diagnosing flu in children, allowing doctors to make more accurate treatment decisions in less time.

Treatment

Essentially, a bout of influenza must be allowed to run its course. Symptoms can be relieved with bed rest and by keeping well hydrated. A steam vaporizer may make breathing easier, and pain relievers will take care of the aches and pain. Food may not seem very appetizing, but an effort should be made to consume nourishing food. Recovery should not be pushed too rapidly. Returning to normal activities too quickly invites a possible relapse or complications.

Drugs

Since influenza is a viral infection, antibiotics are useless in treating it. However, antibiotics are frequently used to treat secondary infections.

Over-the-counter medications are used to treat flu symptoms, but it is not necessary to purchase a medication marketed specifically for flu symptoms. Any medication that is designed to relieve symptoms, such as pain and coughing, will provide some relief. Medications containing alcohol, however, should be avoided because of the dehydrating effects of alcohol. The best medicine for symptoms is simply an analgesic, such as aspirin, acetaminophen, or naproxen. Without a doctor's approval, aspirin is generally not recommended for people under 18 owing to its association with Reye's syndrome, a rare aspirin-associated complication seen in children recovering from the flu. To be on the safe side, children should receive acetaminophen or ibuprofen to treat their symptoms.

There are four antiviral drugs marketed for treating influenza as of 2003. To be effective, treatment should begin no later than two days after symptoms appear. Antivirals may be useful in treating patients who have weakened immune systems or who are at risk for developing serious complications. They include amantadine (Symmetrel, Symadine) and rimantadine (Flumandine), which work against Type A influenza, and zanamavir (Relenza) and oseltamavir phosphate (Tamiflu), which work against both Types A and B influenza. Amantadine and rimantadine can cause side effects such as nervousness, anxiety, lightheadedness, and nausea. Severe side effects include seizures, delirium, and hallucination, but are rare and are nearly always limited to people who have kidney problems, seizure disorders, or psychiatric disorders. The new drugs zanamavir and oseltamavir phosphate have few side effects but can cause dizziness, jitters, and insomnia.

Alternative treatments

There are several alternative treatments that may help in fighting off the virus and recovering from the flu, in addition to easing flu symptoms.

• Acupuncture and acupressure. Both are said to stimulate natural resistance, relieve nasal congestion and headaches, fight fever, and calm coughs, depending on the acupuncture and acupressure points used.
• Aromatherapy. Aromatherapists recommend gargling daily with one drop each of the essential oils of tea tree (Melaleuca spp.) and lemon mixed in a glass of warm water. If already suffering from the flu, two drops of tea tree oil in a hot bath may help ease the symptoms. Essential oils of eucalyptus (Eucalyptus globulus) or peppermint (Mentha piperita) added to a steam vaporizer may help clear chest and nasal congestion.
• Herbal remedies. Herbal remedies can be used stimulate the immune system (echinacea), as antivirals (Hydrastis canadensis) goldenseal and garlic (Allium sativum), or directed at whatever symptoms arise as a result of the flu. For example, an infusion of boneset (Eupatroium perfoliatum) may counteract aches and fever, and yarrow (Achillea millefolium) or elderflower tinctures may combat chills.
• Homeopathy. To prevent flu, a homeopathic remedy called Oscillococcinum may be taken at the first sign of flu symptoms and repeated for a day or two. Although oscillococcinum is a popular flu remedy in Europe, however, a research study published in 2003 found it to be ineffective. Other homeopathic remedies recommended vary according to the specific flu symptoms present. Gelsemium (Gelsemium sempervirens) is recommended to combat weakness accompanied by chills, a headache, and nasal congestion. Bryonia (Bryonia alba) may be used to treat muscle aches, headaches, and a dry cough. For restlessness, chills, hoarseness, and achy joints, poison ivy (Rhus toxicodendron) is recommended. Finally, for achiness and a dry cough or chills, Eupatorium perfoliatum is suggested.
• Hydrotherapy. A bath to induce a fever will speed recovery from the flu by creating an environment in the body where the flu virus cannot survive. The patient should take a bath as hot as he/she can tolerate and remain in the bath for 20-30 minutes. While in the bath, the patient drinks a cup of yarrow or elderflower tea to induce sweating. During the bath, a cold cloth is held on the forehead or at the nape of the neck to keep the temperature down in the brain. The patient is assisted when getting out of the bath (he/she may feel weak or dizzy) and then gets into bed and covers up with layers of blankets to induce more sweating.
• Traditional Chinese medicine (TCM). Practitioners of TCM recommend mixtures of herbs to prevent flu as well as to relieve symptoms once a person has fallen ill. There are several different recipes for these remedies, but most contain ginger and Japanese honeysuckle in addition to other ingredients.
• Vitamins. For adults, 2-3 grams of vitamin C daily may help prevent the flu. Increasing the dose to 5-7 grams per day during the flu can felp fight the infection. (The dose should be reduced if diarrhea develops.)

Prognosis

Following proper treatment guidelines, healthy people under the age of 65 usually suffer no long-term consequences associated with flu infection. The elderly and the chronically ill are at greater risk for secondary infection and other complications, but they can also enjoy a complete recovery.

Most people recover fully from an influenza infection, but it should not be viewed complacently. Influenza is a serious disease, and approximately 1 in 1,000 cases proves fatal.

Prevention

The Centers for Disease Control and Prevention recommend that people get an influenza vaccine injection each year before flu season starts. In the United States, flu season typically runs from late December to early March. Vaccines should be received two to six weeks prior to the onset of flu season to allow the body enough time to establish immunity. Adults only need one dose of the yearly vaccine, but children under nine years of age who have not previously been immunized should receive two doses with a month between each dose.

Each season's flu vaccine contains three virus strains that are the most likely to be encountered in the coming flu season. When there is a good match between the anticipated flu strains and the strains used in the vaccine, the vaccine is 70-90% effective in people under 65. Because immune response diminishes somewhat with age, people over 65 may not receive the same level of protection from the vaccine, but even if they do contract the flu, the vaccine diminishes the severity and helps prevent complications.

The virus strains used to make the vaccine are inactivated and will not cause the flu. In the past, flu symptoms were associated with vaccine preparations that were not as highly purified as modern vaccines, not to the virus itself. In 1976, there was a slightly increased risk of developing Guillain-Barré syndrome, a very rare disorder, associated with the swine flu vaccine. This association occurred only with the 1976 swine flu vaccine preparation and has never recurred.

Serious side effects with modern vaccines are extremely unusual. Some people experience a slight soreness at the point of injection, which resolves within a day or two. People who have never been exposed to influenza, particularly children, may experience one to two days of a slight fever, tiredness, and muscle aches. These symptoms start within 6-12 hours after the vaccination.

It should be noted that certain people should not receive an influenza vaccine. Infants six months and younger have immature immune systems and will not benefit from the vaccine. Since the vaccines are prepared using hen eggs, people who have severe allergies to eggs or other vaccine components should not receive the influenza vaccine. As an alternative, they may receive a course of amantadine or rimantadine, which are also used as a protective measure against influenza. Other people who might receive these drugs are those that have been immunized after the flu season has started or who are immunocompromised, such as people with advanced HIV disease. Amantadine and rimantadine are 70-90% effective in preventing influenza.

Certain groups are strongly advised to be vaccinated because they are at increased risk for influenza-related complications:

• All people 65 years and older
• Residents of nursing homes and chronic-care facilities, regardless of age
• Adults and children who have chronic heart or lung problems, such as asthma
• Adults and children who have chronic metabolic diseases, such as diabetes and renal dysfunction, as well as severe anemia or inherited hemoglobin disorders
• Children and teenagers who are on long-term aspirin therapy

• Women who will be in their second or third trimester during flu season or women who are nursing
• Anyone who is immunocompromised, including HIV-infected persons, cancer patients, organ transplant recipients, and patients receiving steroids, chemotherapy, or radiation therapy
• Anyone in contact with the above groups, such as teachers, care givers, health-care personnel, and family members
• Travelers to foreign countries.

A person need not be in one of the at-risk categories listed above, however, to receive a flu vaccination. Anyone who wants to forego the discomfort and inconvenience of an influenza attack may receive the vaccine.

As of early 2003, researchers are working on developing an intranasal flu vaccine in aerosol form. An aerosol vaccine using a weakened form of Type A influenza virus has been tested in pilot studies and awaits further clinical trials.

Resources

Books

Beers, Mark H., MD, and Robert Berkow, MD, editors. "Respiratory Viral Diseases: Influenza." Section 13, Chapter 162. In The Merck Manual of Diagnosis and Therapy. Whitehouse Station, NJ: Merck Research Laboratories, 2004.

Pelletier, Kenneth R., MD. The Best Alternative Medicine, Part II. "CAM Therapies for Specific Conditions: Colds/Flu." New York: Simon & Schuster, 2002.

Periodicals

Elkins, Rita. "Combat Colds and Flu." Let's Live. 68 (January 2000): 81+.

Jonas, W. B., T. J. Kaptchuk, and K. Linde. "A Critical Overview of Homeopathy." Annals of Internal Medicine 138 (March 4, 2003): 393-399.

Krug, R. M. "The Potential Use of Influenza Virus as an Agent for Bioterrorism." Antiviral Research 57 (January 2003): 147-150.

Oxford, J. S., S. Bossuyt, S. Balasingam, et al. "Treatment of Epidemic and Pandemic Influenza with Neuraminidase and M2 Proton Channel Inhibitors." Clinical Microbiology and Infection 9 (January 2003): 1-14.

Roth, Y., J. S. Chapnik, and P. Cole. "Feasibility of Aerosol Vaccination in Humans." Annals of Otology, Rhinology, and Laryngology 112 (March 2003): 264-270.

Shortridge, K. F., J. S. Peiris, and Y. Guan. "The Next Influenza Pandemic: Lessons from Hong Kong." Journal of Applied Microbiology 94, Supplement (2003): 70S-79S.

Storch, G. A. "Rapid Diagnostic Tests for Influenza." Current Opinion in Pediatrics 15 (February 2003): 77-84.

Thompson, W. W., D. K. Shay, E. Weintraub, et al. "Mortality Associated with Influenza and Respiratory Syncytial Virus in the United States." Journal of the American Medical Association 289 (January 8, 2003): 179-186.

Organizations

Centers for Disease Control and Prevention. 1600 Clifton Rd., NE, Atlanta, GA 30333. (800) 311-3435, (404) 639-3311. http://www.cdc.gov.

National Institute of Allergy and Infectious Diseases (NIAID). 31 Center Drive, MSC 2520, Bethesda, MD 20892-2520. http://www.niaid.nih.gov.

Other

NIAID Fact Sheet: Flu. Bethesda, MD: NIAID, January 2003. http://www.niaid.nih.gov/factsheets/flu.htm.

Key terms

Bioterrorism — The intentional use of disease-causing microbes or other biologic agents to intimidate or terrorize a civilian population for political or military reasons. Type A influenza virus could be used as an agent of bioterrorism.

Common cold — A mild illness caused by a upper respiratory viruses. Usual symptoms include nasal congestion, coughing, sneezing, throat irritation, and a low-grade fever.

Epidemic — A widespread regional disease outbreak.

Guillain-Barré syndrome — Also called acute idiopathic polyneuritis, this condition is a neurologic syndrome that can cause numbness in the limbs and muscle weakness following certain viral infections.

Pandemic — Worldwide outbreak of an infection, afflicting millions of victims.

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influenza /in·flu·en·za/ (in″floo-en´zah) [Ital.] an acute viral infection of the respiratory tract, occurring in isolated cases, epidemics, and pandemics, caused by serologically distinct strains of viruses (influenzaviruses) designated A, B, and C; marked by inflammation of the nasal mucosa, pharynx, and conjunctiva, headache, myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system influen´zal

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in·flu·en·za (nfl-nz)

n.

An acute contagious viral infection, commonly occurring in epidemics or pandemics, and characterized by inflammation of the respiratory tract and by the sudden onset, fever, chills, muscular pain, headache, and severe prostration. Also called grippe.

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influ·enzal adj.

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influenza

[in′flo̅o̅·en′zə]

Etymology: It, influence

a highly contagious infection of the respiratory tract caused by orthomyxovirus and transmitted by airborne droplet infection. It occurs in isolated cases, epidemics, and pandemics. Symptoms include sore throat, cough, fever, muscular pains, and weakness. The incubation period is brief (from 1 to 3 days), and the onset is usually sudden, with chills, fever, respiratory symptoms, headache, myalgia, and extreme fatigue. Treatment is symptomatic and usually involves bed rest, acetaminophen, and drinking of fluids. Fever and constitutional symptoms distinguish influenza from the common cold. Complete recovery in 3 to 10 days is the rule, but bacterial pneumonia may occur among high-risk patients, such as the elderly, the very young, and people who have chronic pulmonary disease, and lead to death. On average, 5%-20% of the population suffer influenza infection annually, and approximately 56,000 die. Three main strains of influenza virus have been recognized: type A, type B, and type C. New strains of the virus emerge at regular intervals and are named according to their geographic origin, for example, Asian flu. Yearly vaccination with the currently prevalent strain of influenza virus is recommended for elderly or debilitated persons and health care personnel. Treatment or prophylaxis in high-risk patients may be achieved with rimantadine. Oseltamavir (oral) and Zanamivir (aerosol), when administered within 48 hours of onset, can lessen the severity and duration of symptoms. Also called

Usage notes: (informal)

flu, grippe, la grippe.

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influenza,

n a viral infection trans-mitted via airborne droplets; highly contagious, with a sudden onset of symptoms including sore throat, headache, fever, chills, and myalgia. Recovery normally occurs within three to ten days but can be fatal.

Influenza.

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influenza (in´flooen´z),

n a highly contagious infection of the respiratory tract caused by a myxovirus and transmitted by airborne droplet infection. Symptoms include sore throat, cough, fever, muscular pains, and weakness. Fever and constitutional symptoms distinguish influenza from the common cold. Three main strains of influenza virus have been recognized: Type A, Type B, and Type C. New strains of the virus emerge at regular intervals and are named according to geographic origin. Asian flu is a Type A influenza.

influenza-virus vaccine,

n an active immunizing agent prescribed for immunization against influenza, generally recommended for at-risk populations, such as the elderly.

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influenza

an acute viral infection of the respiratory tract, occurring usually in epidemics, and pandemics. Influenza viruses are single-stranded RNA viruses belonging to the family Orthomyxoviridae, which contains three genera termed A, B and C. All of the viruses of interest to veterinarians are influenza type A viruses and include those causing equine influenza, swine influenza and avian influenza (fowl plague).

Common usage is to diagnose influenza or 'flu' in many nonspecific respiratory infections in animals or those caused by other viruses, but this is etiologically incorrect. Typical examples are cat flu and goose influenza.

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influenza

Infectious disease A viral infection which costs the health care system–US ± $12 billion/yr; it causes 10-40,000 excess deaths/yr, 80% in the elderly, most preventable by annual vaccination  Complications Secondary bacterial infections–eg, otitis media, viral URIs, Reye syndrome, liver and CNS disease Management Oseltamivir, zanamivir, a selective neuraminidase inhibitor, ↓ symptoms in influenza A or B Prevention Annual vaccination. See Cold-adapted influenza vaccine, Zanamivir.

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Patient discussion about Influenza w/ other respiratory manifestations.

Q. Do I have Bronchitis? I had a cold and since then I have a severe cough which I can't seem to get rid of. Is this bronchitis? Does it need to be treated or will it go away by itself?

A. Bronchitis most commonly occurs after an upper respiratory infection such as the common cold or a sinus infection. You may see symptoms such as fever with chills, muscle aches, nasal congestion, and sore throat. Most cases of bronchitis clear up on their own, however if you have complications, go see your doctor. If the cough is very severe and interrupts your sleep, if you are wheezing or have a fever for longer than a few days, then you should see your Doctor.

Q. Who Should Receive the Flu Vaccine? Should I go get vaccinated for the flu? I have been told it is advised only for certain people, so who should receive this vaccine?

A. Vaccination against the influenza virus, which causes the flu, with the influenza vaccine, is often recommended for high-risk groups, such as children and the elderly.
http://www.5min.com/Video/Flu-Vaccine-9546

Q. Do Antibiotics cure a cold? I have a cold and a runny nose, should I take Antibiotics?

A. Taking antbiotics when you only have a cold can harm your chances of the effectiveness of using antibiotics when you have a severe problem. Your body can build up an immunity to antibiotics so it is only recommended to take them when your immune system can't fight off the infections. Most of the time, a cold just needs to run it's course , so drinking plenty of fluids and resting can allow your body to rejuvinate and fight the cold. To help prevent colds and viruses, look for products that help to maintain a good immune system like vitamin C. Aloe juice is another good product for your immune system. When we deal with stress and don't get enough rest, we cause havoc on our immune system, so prevention can be the best thing to do. Wishing you well!