splenomegaly (redirected from Inflammatory/immune-related)

splenomegaly /sple·no·meg·a·ly/ (-meg´ah-le) enlargement of the spleen.

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congestive splenomegaly  Banti's disease; splenomegaly secondary to portal hypertension.

hemolytic splenomegaly  that associated with any disorder causing increased erythrocyte degradation.

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sple·no·meg·a·ly (spln-mg-l, spln-)

n.

Enlargement of the spleen. Also called megalosplenia.

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Splenomegaly

Abnormal enlargement of the spleen. Splenomegaly is a major diagnostic criterion of PV.

Mentioned in: Hemoglobinopathies, Polycythemia Vera, Splenectomy, Thalassemia

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splenomegaly

[splē′nōmeg′əlē, splen′-]

Etymology: Gk, splen + megas, large

an abnormal enlargement of the spleen, as is associated with portal hypertension, hemolytic anemia, Niemann-Pick disease, or malaria.

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splenomegaly (spleˈ·nō·meˑ·g·lē),

n an abnormal increase in the size of the spleen; often associated with hemolytic anemia, mononucleosis, leukemia, portal hypertension, or malaria.

Splenomegaly.

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splenomegaly (splē´nōmeg´lē),

n an abnormal enlargement of the spleen, usually associated with portal hypertension, hemolytic anemia, and malaria.

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splenomegaly

enlargement of the spleen. Is largely without clinical signs but it may be palpated during an examination through the abdominal wall in dogs and cats, rectally in horses and not at all in ruminants. The enlargements may be caused by abscess or neoplasm or there may be a diffuse enlargement caused by accumulation of hemolyzed red cells.

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asymmetrical splenomegaly

usually the result of trauma or neoplasia.

congestive splenomegaly

in animals, most often caused by splenic torsion.

hemolytic splenomegaly

that associated with hemolytic anemia.

siderotic splenomegaly

splenomegaly with deposit of iron and calcium.

symmetrical splenomegaly

usually caused by congestion or infiltration of the splenic tissue.

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splenomegaly

Enlarged spleen Enlargement of spleen for any reason, which is usually a manifestation of underlying disease; the only specific finding in splenomegaly is dragging sensation in the upper right quadrant; megalic spleens may reach 4.0+ kg–eg, in agnogenic myeloid metaplasia

Splenomegaly

Congestion Cirrhosis, CHF, thrombosis of portal or splenic veins

Infection

• Bacteria Brucellosis, infective carditis agents, syphilis, TB, typhoid fever

• Fungi Histoplasmosis

• Parasites Echinococcosis, leishmaniasis, malaria, schistosomiasis, toxoplasmosis, trypanosomiasis

• Viruses CMV, EBV

Inflammatory/immune-related Rheumatoid arthritis, SLE

Hematopoietic disease/Lymphoid function

• Malignant Leukemias, eg ALL, CLL, myeloproliferative disorders–eg agnogenic myeloid metaplasia, CML, multiple myeloma, polycythemia vera; lymphomas–Hodgkin's disease, NHL

• Nonmalignant Hemolytic anemia, histiocytosis, ITP

Storage diseases Gaucher's disease, mucopolysaccharidosis, Niemann-Pick disease

Etc Amyloidosis, cysts, hypersplenism, metastases, primary tumors