NOS2

(redirected from Inducible NO synthase)

NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
Mentioned in ?
References in periodicals archive ?
Muscular structure, enzyme activity, constitutive and inducible nitric oxide (NO) synthases (endothelial NO oxide synthase [eNOS], neuronal NO synthase [nNOS] and inducible NO synthase [iNOS]), nitrites, nitrates, nitrotyrosine, and the presence of macrophages were analyzed.
A key proinflammatory mediator produced in the intestinal mucosa is the free radical nitric oxide (NO), synthesized by inducible NO synthase (iNOS).
Inducible NO synthase (iNOS)[3] activity stimulated at the site of infection is primarily responsible for the sustained release of NO (2).