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incomplete penetrance |
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penetrance the frequency with which a heritable trait is manifested by individuals carrying the principal gene or genes conditioning it. incomplete penetrance when penetrance is less than 100%. incomplete penetrance adjective Referring to the presence of a gene that is not phenotypically expressed in all members of a family with the gene. See Penetrance. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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In recent years, however, geneticists have begun to suspect that Hirschsprung's disease follows a pattern called autosomal dominance with incomplete penetrance. The condition affects 1:2,000 to 1:10,000 newborns and is passed to offspring as a mendelian recessive with incomplete penetrance. Paigen, the Jackson Laboratory scientist who directs Nishina and Naggert's research, says a genetic phenomenon called incomplete penetrance could account for the fact that myocardial infarctions strike mostly men and postmenopausal women. |
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