immunotoxin

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immunotoxin

/im·mu·no·tox·in/ (im´u-no-tok″sin) any antitoxin.

immunotoxin

(ĭm′yə-nō-tŏk′sĭn, ĭ-myo͞o′-)
n.
A hybrid molecule formed by binding a toxin to a monoclonal antibody, used to destroy tumor cells.

immunotoxin (IT)

[-tok′sin]
a toxin that is attached to a monoclonal antibody and used to destroy a specific type of target cell. An example is the plant toxin ricin, which inhibits protein synthesis in tumor cells that are recognized by the antibodies to which ricin is attached.

immunotoxin

an antibody attached to a specific toxic agent that is used to destroy specific cancer cells. Although experimental at present, these so-called ‘magic bullets’ hold out great hope as a new form of cancer CHEMOTHERAPY.

immunotoxin

an antitoxin.
References in periodicals archive ?
sup][15] The second-generation immunotoxins removed the cell-binding domain from the toxin part, thus affecting a much smaller amount of normal cells in animal models.
IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity.
Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM195/rGEL), in patients with advanced myeloid malignancies," Haematologica, vol.
Because a variety of disorders are treated with bone marrow transplants, the use of immunotoxins to eliminate harmful cells prior to the procedure could have a significant impact in increasing transplant success rates and reducing hospital time.
Aflatoxins are immunotoxins that frequently contaminate staple foods in The Gambia and other parts of sub-Saharan Africa, resulting in high exposure throughout life.
The company has four technologies: engineered mAbs, mAb-drug conjugates, single-chain immunotoxins and antibody-directed enzyme prodrug therapy (ADEPT).
By fusing a cell-killing toxin to such an antibody, neuroscientists have created immunotoxins that seek out specific classes of nerve cells.
develop assays to detect human immunoglobulins against humanized or primatized antibodies, immunonuclides, immunotoxins, their individual components, and neoantigens formed by the linked antibody/toxin/nuclide".
Such toxins can either be used directly in treatment or as components of immunotoxins (62-64).
As an exciting new frontier, BBBD optimizes drug delivery to tumor, and also provides a technique for administering new agents such as immunotoxins and gene therapy across the blood-brain barrier for the treatment of numerous central nervous system diseases.
Alternatively, immunotoxins (MoAbs conjugated with powerful cytotoxins such as the plant alkaloid ricin) are employed to selectively kill tumor cells.