Saporin, the killer that scientists have employed in many immunotoxins
as well, interferes with ribosomes, which are protein-synthesizing factories inside all cells.
The anti-CD22 immunotoxins
GCR-3888 and GCR-8015 comprise a dsFv that targets the CD22 receptor, fused with a specifically engineered toxin molecule that minimizes non-targeted toxicity, resulting in a highly specific, highly potent therapeutic molecule.
Vitetta and her colleagues encountered vascular leak syndrome when they began testing immunotoxins
in cancer patients.
are drugs created by linking an antibody to a portion of bacterial or plant toxin to destroy cells expressing the molecule to which the antibody binds.
5 Will Next-Generation Immunotoxins
Impact the Market to 2024?
The present invention also provides a method for decreasing the number of immune cells in an individual using the heat shock protein immunotoxins
of the present invention.
A number of immunotoxins
currently in clinical trials are antibody-based reagents.
In a chapter of the text that reviews immunotoxins
, Susanna Rybak, Ph.
Cytotoxic therapeutic agents or immunotoxins
according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.
His current research continues to focus on the use of immunotoxins
to treat cancer.
For example, functional monoclonal antibodies comprising a heavy chain and a light chain of an immunoglobulin, and functional immunotoxins
comprising an antibody domain and an oxidase toxin may be produced using the Yeast expression system of the present invention.
12 Pseudomonas Exotoxin A-Based Immunotoxins
for Targeted Cancer Therapy