proteasome

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pro·te·a·some

(prō'tē-ă-sōm),
Cytoplasmic organelle, composed of a cylindric core particle bound by two regulatory particles at each end, responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targeted protein's lysine residue.
See also: ubiquitin-protease pathway.
[protease + -some ]

proteasome

(prō′tē-ə-sōm′)
n.
A cellular protein complex consisting of proteolytic enzymes that degrade endogenous proteins, especially those that are damaged, pathogenic, or no longer of use.

proteasome

, proteosome (prō′tē-ă-sōm″)
An enzymatic (protease) cell organelle that degrades misfolded or damaged proteins and modulates the quantity of regulatory proteins in the cell. The breakdown of proteins by proteasomes (proteolysis) is triggered when damaged proteins are tagged by ubiquitin.

Proteasome

A large, cylindrical protein complex of several sub-units, present in the cytoplasm and nucleus of all cells and an essential component in cell metabolism. The function of the proteasome is to act as a kind of shredder, degrading unwanted proteins that have been tagged for destruction with UBIQUITIN chains. It strips proteins of their ubiquitin, unfolds them and catalyzed them to peptides. Proteasomes have aroused much interest as therapeutic trargets in cancer. The proteasome 26S is involved both in the induction and repression of APOPTOSIS. See also POLYUBIQUITINATION.
References in periodicals archive ?
The collaboration contemplates the creation and development of orally bioavailable, selective inhibitors of the immunoproteasome subunits to target autoimmunity.
PSMB8 encodes [sz]2 subunit of immunoproteasome and shares a similar mechanism on the protein degradation and immune response like PSMB9 .
The immunoproteasome in antigen processing and other immunological functions.
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.
Immune and non-immune functions of the immunoproteasome.
5] in standard proteasomes, which are replaced during de novo biogenesis of immunoproteasomes by immunosubunits [beta]1i, [beta]2i, and [beta]5i, the transcription of which is induced by several cytokines, such as interferon-[gamma] (20).

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