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imidazole |
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imidazole /im·id·az·ole/ (im″id-az´ōl) 1. a heterocyclic organic compound in which two of five ring atoms are nitrogen; used as an insecticide. 2. any of a class of antifungal compounds containing this structure.
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| 12,14,17,19) In 1978, Cosgrove et al theorized that combining amphotericin B with an imidazole antifungal might result in antagonism because the two agents competed for the same binding sites on cell membranes. The new agent, which is based on the imidazole compound, has a broad spectrum and strong antifungal activity. The patent, entitled "Use of Imidazole for the Treatment of Diseases Characterized by Neovascularization," protects the use of specific small molecules in a class of compounds called imidazoles for the treatment of angiogenic conditions where neovascularization (new blood vessel formation) contributes to the progression of the disease by supplying nourishment to the diseased area. |
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