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imatinib

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imatinib /im·at·i·nib/ (ĭ-mă´tĭ-nib″) an antineoplastic used as the mesylate salt in the treatment of chronic myeloid leukemia, inhibiting an abnormal enzyme form constitutively produced in the disease.
imatinib
[imă′tĭnib′]
an inhibitor acting specifically on an abnormal enzyme form that is created by the Philadelphia chromosome abnormality and present in chronic myeloid leukemia. It is administered orally as the mesylate salt in the treatment of chronic myeloid leukemia during blast crisis, accelerated phase, or chronic phase after failure of interferon-alpha therapy.

imatinib [ĭ-mă´tĭ-nib″]
an inhibitor acting specifically on an abnormal enzyme form that is created by the Philadelphia chromosome abnormality and present in chronic myeloid leukemia. It is used in the treatment of chronic myeloid leukemia during blast crisis, accelerated phase, or chronic phase after failure of interferon-α therapy, administered orally as the mesylate salt.


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Imatinib has so far proved to inhibit cell division in intestinal tumour cells in vitro and in mice.
Cell culture studies have shown that imatinib inhibits ACC growth and that there is a synergistic interaction between imatinib and cisplatin.
Recently, the US Food and Drug Administration (FDA) approved imatinib for the post-surgery treatment of adult patients following complete surgical removal of so-called "Kit (CD117)-positive" gastrointestinal stromal tumors, accoring to a Novartis statement.
 
 
 
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