IgA nephropathy

nephropathy /ne·phrop·a·thy/ (nĕ-frop´ah-the) disease of the kidneys.nephropath´ic

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analgesic nephropathy  interstitial nephritis with renal papillary necrosis, seen with abuse of analgesics such as aspirin or acetaminophen.

diabetic nephropathy  the nephropathy seen in later stages of diabetes mellitus, with first hyperfiltration, renal hypertrophy, microalbuminuria, and hypertension, and later proteinuria and end-stage renal disease.

gouty nephropathy  any of a group of chronic kidney diseases associated with the abnormal production and excretion of uric acid.

HIV-associated nephropathy  renal pathology in patients infected with the human immunodeficiency virus, a condition resembling focal segmental glomerulosclerosis.

IgA nephropathy  see under glomerulonephritis.

ischemic nephropathy  nephropathy resulting from partial or complete obstruction of a renal artery and the accompanying ischemia; there is a significant reduction in the glomerular filtration rate.

membranous nephropathy  see under glomerulonephritis.

minimal change nephropathy  see under disease.

obstructive nephropathy  nephropathy from obstruction of the urinary tract with hydronephrosis and a slowed glomerular filtration rate.

potassium-losing nephropathy  persistent urinary potassium losses in the presence of hypokalemia, such as in metabolic alkalosis or intrinsic renal disease.

reflux nephropathy  childhood pyelonephritis in which the renal scarring results from vesicoureteric reflux, with radiological appearance of intrarenal reflux.

salt-losing nephropathy  any intrinsic renal disease causing abnormal urinary sodium loss to the point of hypotension.

sickle cell nephropathy  chronic kidney disease in sickle cell disease, including vascular abnormalities, fibrosis, and an increased glomerular filtration rate.

urate nephropathy , uric acid nephropathy any of a group of kidney diseases with hyperuricemia, including an acute form, a chronic form (gouty n.), and nephrolithiasis with uric acid calculi.

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IgA nephropathy

Berger's disease, IgA glomerulonephritis Nephrology Idiopathic IgA nephropathy is the most common form of primary glomerulonephritis in the world; primary IN is mediated by immune complexes and defined immunohistochemically by glomerular deposition of IgA; in 20-40% of Pts, it progresses to renal failure 5-25 yrs after diagnosis; IN may occur in HIV-infected Pts Clinical Macroscopic hematuria which may coincide with an URI and be accompanied by flank pain, a presentation typical of younger Pts; older Pts tend to be asymptomatic and IN is detected by sediment and proteinuria Treatment ACE-inhibitors, corticosteroids, n-3 polyunsaturated fatty acids provided in dietary fish oil may slow progression of renal failure, kidney transplantation Prognosis More rapid progression occurs in ♂, older Pts, HTN, persistent proteinuria, baseline of impaired renal function, glomerulosclerosis or interstitial fibrosis at the time of initial evaluation