IgA nephropathy

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1. any disease of the kidneys. adj., adj nephropath´ic.
2. any disease of the kidneys; see also nephritis. Called also nephrosis. adj., adj nephropath´ic.
AIDS nephropathy former name for HIV-associated nephropathy.
analgesic nephropathy interstitial nephritis with renal papillary necrosis, seen in patients with a history of abuse of analgesics such as aspirin or acetaminophen alone or in combination.
diabetic nephropathy the nephropathy that commonly accompanies later stages of diabetes mellitus; it begins with hyperfiltration, renal hypertrophy, microalbuminuria, and hypertension; in time proteinuria develops, with other signs of decreasing function leading to end-stage renal disease.
gouty nephropathy any of a group of chronic kidney diseases associated with the abnormal production and excretion of uric acid.
heavy metal nephropathy the kidney damage resulting from any of various forms of heavy metal poisoning, usually in the form of tubulointerstitial nephritis. The most common metals involved are cadmium, lead, and mercury.
HIV-associated nephropathy renal pathology in patients infected with the human immunodeficiency virus, similar to focal segmental glomerulosclerosis, with proteinuria, enlarged kidneys, and dilated tubules containing proteinaceous casts; it may progress to end-stage renal disease within weeks.
hypokalemic nephropathy nephropathy with hypokalemia, interstitial nephritis, swelling and vacuolization of proximal renal tubules, and progressive renal failure, resulting from conditions such as oncotic overloading of the kidney filtration mechanisms by sugars. See also potassium-losing nephropathy.
IgA nephropathy a chronic form marked by hematuria and proteinuria and by deposits of IgA immunoglobulin in the mesangial areas of the renal glomeruli, with subsequent reactive hyperplasia of mesangial cells. Called also Berger's disease and IgA glomerulonephritis.
ischemic nephropathy nephropathy resulting from partial or complete obstruction of a renal artery with ischemia, accompanied by a significant reduction in the glomerular filtration rate.
lead nephropathy the kidney damage that accompanies lead poisoning; lead deposits appear in the epithelium of the proximal tubules and as nuclear inclusions in cells. In time this leads to tubulointerstitial nephritis with chronic renal failure and other symptoms.
membranous nephropathy membranous glomerulonephritis.
minimal change nephropathy minimal change disease.
obstructive nephropathy nephropathy caused by obstruction of the urinary tract (usually the ureter), with hydronephrosis, slowing of the glomerular filtration rate, and tubular abnormalities.
potassium-losing nephropathy hypokalemic nephropathy after persistent potassium loss; it may be seen in metabolic alkalosis, adrenocortical hormone excess, or in intrinsic renal disease such as renal tubular acidosis or hyperplasia of juxtaglomerular cells. Called also potassium-losing nephritis.
reflux nephropathy childhood pyelonephritis in which the renal scarring results from vesicoureteric reflux, with radiological appearance of intrarenal reflux.
salt-losing nephropathy intrinsic renal disease causing abnormal urinary sodium loss in persons ingesting normal amounts of sodium chloride, with vomiting, dehydration, and vascular collapse. Called also salt-losing nephritis.
urate nephropathy (uric acid nephropathy) any of a group of kidney diseases occurring in patients with hyperuricemia, including an acute form, a chronic form (gouty nephropathy), and nephrolithiasis with formation of uric acid calculi.

fo·cal glo·mer·u·lo·ne·phri·tis

glomerulonephritis affecting a small proportion of renal glomeruli that commonly presents with hematuria and may be associated with acute upper respiratory infection in young males, not usually due to streptococci; associated with IgA deposits in the glomerular mesangium and may also be associated with systemic disease, as in Henoch-Schönlein purpura.

IgA nephropathy

Berger's disease, IgA glomerulonephritis Nephrology Idiopathic IgA nephropathy is the most common form of primary glomerulonephritis in the world; primary IN is mediated by immune complexes and defined immunohistochemically by glomerular deposition of IgA; in 20-40% of Pts, it progresses to renal failure 5-25 yrs after diagnosis; IN may occur in HIV-infected Pts Clinical Macroscopic hematuria which may coincide with an URI and be accompanied by flank pain, a presentation typical of younger Pts; older Pts tend to be asymptomatic and IN is detected by sediment and proteinuria Treatment ACE-inhibitors, corticosteroids, n-3 polyunsaturated fatty acids provided in dietary fish oil may slow progression of renal failure, kidney transplantation Prognosis More rapid progression occurs in ♂, older Pts, HTN, persistent proteinuria, baseline of impaired renal function, glomerulosclerosis or interstitial fibrosis at the time of initial evaluation

IgA nephropathy

A form of GLOMERULONEPHRITIS associated with deposition of the immunoglobulin IgA in the glomeruli of the kidneys. There is occasional blood and protein in the urine and kidney failure may occur. The cause is unknown and there is no effective treatment.
References in periodicals archive ?
A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases," PLoS ONE, vol.
5%), followed by membranous nephropathyand IgA nephropathy.
As mentioned earlier IgA1 type immunoglobulin deposition is the main feature of IgA nephropathy.
Colin Hislop said, "Regaining full worldwide control of blisibimod development, and in particular the IgA nephropathy program, is exciting as we are now free to consider additional approaches including the potential examination of the clinical data from the BRIGHT-SC study at an earlier time point than originally planned.
Taking gluten out of the diet is clearly helpful for IgA nephropathy, but may not have much impact on FSGS or other types of kidney inflammation.
This article also provided us with a good opportunity to explain the rare association between sarcoidosis and IgA nephropathy.
IgA nephropathy was reported in only four patients in this study.
Elevated levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy.
Focal segmental glomerulosclerosis was found in 22 cases (22%) followed by membranous nephropathy in 17 cases (17%), IgA nephropathy and mesangioproliferative glomerulonephritis in 10 cases (10%) each.
This is especially important in cases of early stage membranous, IgA nephropathy (IgAN), Lupus nephritis and IgM nephropathy (IgMN), as these entities can only be diagnosed by correlating the microscopic, immunoflorescence findings and clinical details.
Summary: TEHRAN (FNA)- Researchers found five regions in the human genome that increase susceptibility to immunoglobulin A (IgA) nephropathy, a major cause of kidney failure worldwide - systematically identifying those that point to a tendency for IgA nephropathy, or a protection against it.
For the first time, researchers have found five regions in the human genome that increase susceptibility to immunoglobulin A (IgA) nephropathy, a major cause of kidney failure worldwide -- systematically identifying those that point to a tendency for IgA nephropathy, or a protection against it.