The network is activated when an antibody (cell receptor) recognises antigen and the network is suppressed when an antibody recognises an idiotope
Molecular characterization of a cross-reactive idiotope
on human immunoglobulins utilizing the VH4-21 gene segment.
Methods are provided for inhibiting the differentiation of adipocyte precursor cells, and for treating or preventing obesity, which comprise administering an effective amount of a composition capable of binding to and activating the EGF receptor, preferably epidermal EGF or a functional derivative thereof, TGF Alpha , an antibody specific for the EGF receptor or an anti-idiotypic antibody specific for an idiotope
on an antibody specific for EGF.
He would have thus comprehended, without sacrificing complexity, the writer's idiotope
We speculate that the patient's antibody binds to an idiotope
on one of the antibodies used in the AxSYM assay and sterically blocks the binding of TSH to that antibody.
It is of course possible that a specific HAAA can also be directed against a particularly immunogenic specific idiotope found only in the peculiar antibody used for therapeutic purposes and not in related immunoglobulins.
In a practical sense, it is not be possible to distinguish an idiotope from a paratope because the binding sites are equivalent.
Although allotypic epitopes can be expressed by many IgG molecules independent of their isotype, idiotopes
that are formed by the variable region on the Fab portion mostly are unique epitopes.