IVIG


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IVIG

Intravenous immunoglobulin, see there.

immunoglobulin

(im?yu-no-glob'yu-lin, im-u?no-) [ immuno- + globulin],

Ig

1. Any of a diverse group of plasma polypeptides that bind antigenic proteins and serve as one of the body's primary defenses against disease. Two different forms exist. The first group of immunoglobulins lies on the surface of mature B cells, enabling them to bind to thousands of antigens. When the antigens are bound, the B plasma cells secrete the second type of immunoglobulins, antigen-specific antibodies, which circulate in the blood and accumulate in lymphoid tissue, esp. the spleen and lymph nodes, binding and destroying specific foreign antigens and stimulating other immune activity. Antibodies also activate the complement cascade, neutralize bacterial toxins and viruses, and function as opsonins, stimulating phagocytosis.

Immunoglobulins are formed by light and heavy (depending on molecular weight) chains of polypeptides made up of about 100 amino acids. These chains determine the structure of antigen-binding sites and, therefore, the specificity of the antibody to one antigen. The five types of immunoglobulins (IgA, IgD, IgE, IgG, IgM) account for approximately 30% of all plasma proteins. Antibodies are one of the three classes of globulins (plasma proteins) in the blood that contribute to maintaining colloidal oncotic pressure. Synonym: antibody See: antigen; B cell

2. Immune globulin.

immunoglobulin A

Abbreviation: IgA
The principal immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva, and tears. It prevents pathogenic bacteria and viruses from invading the body through the mucosa of the gastrointestinal, pulmonary, and genitourinary tracts. Its presence in colostrum and breast milk helps prevent infection in breast-feeding infants.

immunoglobulin D

Abbreviation: IgD
An immunoglobulin that is present on the surface of B lymphocytes and acts as an antigen receptor.

immunoglobulin E

Abbreviation: IgE
An immunoglobulin that attaches to mast cells in the respiratory and intestinal tracts and plays a major role in allergic reactions. About 50% of patients with allergies have increased IgE levels. IgE is also important in the formation of reagin, a type of immunoglobulin gamma E (IgGE), found in the blood of individuals with an atopic hypersensitivity.

immunoglobulin G

Abbreviation: IgG
The principal immunoglobulin in human serum. Because IgG moves across the placental barrier, it is important in producing immunity in the infant before birth. It is the major antibody for antitoxins, viruses, and bacteria. It also activates complement and serves as an opsonin. As gamma globulin, IgG may be given to provide temporary resistance to hepatitis or other diseases.

intravenous immunoglobulin

Abbreviation: IVIG
A solution containing concentrated human immunoglobulins (antibodies), primarily IgG. IVIG has numerous uses in health care, including as replacement therapy for patients with primary immune deficiencies; as a treatment for those with Kawasaki disease, bullous pemphigoid, Guillain-Barré syndrome, idiopathic thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, and other immune-mediated illnesses; and as a means of providing patients with passive immunity against infectious diseases.

immunoglobulin M

Abbreviation: IgM
An immunoglobulin formed in almost every immune response during the early period of the reaction. IgM controls the A, B, O blood group antibody responses and is the most efficient antibody in stimulating complement activity. Its size prevents it from moving across the placenta to the fetus.

intravenous immunoglobulin

Abbreviation: IVIG
A solution containing concentrated human immunoglobulins (antibodies), primarily IgG. IVIG has numerous uses in health care, including as replacement therapy for patients with primary immune deficiencies; as a treatment for those with Kawasaki disease, bullous pemphigoid, Guillain-Barré syndrome, idiopathic thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, and other immune-mediated illnesses; and as a means of providing patients with passive immunity against infectious diseases.
See also: immunoglobulin
References in periodicals archive ?
However, the efficacy and superiority between treatment of corticosteroids and IVIG cannot be assessed in this study due to small sample size.
Purpose of this study is to compare the therapeutic outcomes of Plasmapheresis and IVIG in terms of improvement in functional status over six months duration in patients from our region.
Other treatments IVIG isn't the only treatment on the horizon.
During the initial 6 months, patients received randomized double-blind treatment with placebo or various doses of IVIG (Gammagard).
The researchers, whose study was published in the Annals of Internal Medicine journal, gave a single low-dose transfusion of IVIG to 13 volunteers with pain syndrome and found it significantly eased the pain in just under 50% of them.
Mean birth weights were significantly higher in the IVIG group at 3,711 g vs.
IVIG infuzyonu sonrasinda, primer immun yetersizligi olan hastalarin serum IL-6, IL-8, IL-1Ra ve TNFalpha duzeylerini yukseldigi ancak IL-beta, IFNgamma veya IL-2 duzeyinde fark olmadigi saptanmistir (14).
Is IVIG a safe and effective alternative to exchange transfusion in a premature infant with hemolysis and hyperbilirubinemia secondary to ABO incompatibility, who has failed phototherapy?
Using this phenomenon, we previously diagnosed and reported a 9-week-old male infant with incomplete KD who was initially treated with high-dose IVIG (2 g/kg) and oral aspirin (100 mg/kg) (5).