ITGB4

ITGB4

A gene on chromosome 17q25 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed of alpha and beta chains). The beta chain encoded by ITGB4 usually associates with alpha 6, serving as a laminin receptor. It plays a key structural role in the hemidesmosomes, regulates keratinocyte polarity and motility and is a central player in the biology of invasive cancer.

Molecular pathology
ITGB4 mutations are associated with epidermolysis bullosa with pyloric atresia.
References in periodicals archive ?
80 for tcPTC has confirmed 4 putative miRNA regulatory pairs: hsamiR-146b-5p with PHKB and IRAK1; hsa-miR-874-3p with ITGB4 within cPTC samples (Table 1, Figure 3).
According to our integrative analysis we report four new regulations in PTC: hsa-miR-146b-5p regulating PHKB (phosphorylase kinase, beta), hsa-miR-146b-5p regulating IRAK1 (interleukin-1 receptor-associated kinase 1) and hsamiR-874-3p regulating ITGB4 (integrin, beta 4) in cPTC samples, and hsa-miR-152-3p regulating TGFA (transforming growth factor, alpha) in fvPTC samples.
Putative regulation of ITGB4 expression by hsamiR-874-3p was observed in cPTC samples and may be also present in fvPTC variant (Figure 3).
Four putative miRNA regulatory pairs were discovered: hsa-miR-146b-5p with PHKB and IRAK1, hsa-miR-874-3p with ITGB4 characteristic for cPTC samples, and hsa-miR-152-3p with TGFA characteristic for fvPTC samples.
Pairs hsa-miR-146b-5p with PHKB (a), hsa-miR-146b-5p with IRAKI, (b) and hsa-miR-874-3p with ITGB4 (c) were selected from best inverse Spearman's correlations (below -0.
001 survival CASP1, CBR1, CRABP2, CSTB, EEF1A1, EIF6, ENO1, FLNA, GAPDH, HMGB2, HSP90AA1, HSP90AB1, HSPA8, HSPB1, ITGB4, KRT14, KRT6A, KRT8, LMNA, NDRG1, PDCD6IP, PRDX2, S100A8, S100A9, SFN, TF, TPM1, TRIM29, TUBB, TUBB3, TXN, VCL, YWHAZ Cancer ANXA2, ENO1, 11 < .
Differential expression of pyloric atresia in junctional epidermolysis bullosa with ITGB4 mutations suggests that pyloric atresia is due to factors other than the mutations and not predictive of a poor outcome: three novel mutations and a review of the literature.
Genomics of Epidermolysis Bullosa EB Type Level of Blistering Genes Simplex Basal cell layer KRT5, KRT14 Hemidesmosomal Basal cell/lamina BPAG2, ITGB4, ITGA6 lucida interface (PLEC1 with muscular dystrophy) Junctional Lamina lucida LAMA3, LAMB3, LAMC2 Dystrophic Sublamina densa COL7A1 Source: Dr.
74) Eleven genes--COL1A2, COL6A1 (collagen), tPA, MMP9 (protease), CDH3, L1CAM, ITGB4, PLXNA3/PLXN3, KRT14/K14 (cell adhesion or cell surface molecule), SEMA3C (semaphorin), and CXCL10/INP10 (chemokine)--were overexpressed in MPM.
In the comparative study with normal cells quoted above, (74) SEMA3C, ITGB4, CDH3, and COL6A1 were highly expressed in the epithelioid MPM subtype; L1CAM, K14, and INP10 were overexpressed in the mixed MPM subtype; and MMP9 and PLXN3 were overexpressed in the sarcomatoid MPM subtype.
L1CAM, INP10, P-cadherin, tPA and ITGB4 over-expression in malignant pleural mesotheliomas revealed by combined use of cDNA and tissue microarray.