ITGB3

ITGB3

A gene on chromosome 17q25 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-3 chain partners with the alpha-IIb chain and acts as a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, vitronectin and platelets. Beta-3 chain partnered with the alpha-5 chain is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
References in periodicals archive ?
Genetic analysis has shown autosomal recessive pathogenic variants in the ITGA2B or ITGB3.
The combined model added expression data from four genes: ITGB3, cellular tumor antigen p53 (TP53), laminin B1 chain (LAMBl), and tissue-type plasminogen activator (PLAT; protein name, t-PA).
ITGAV, ITGB3, beta-catenin and PECAM1), tubule formation factors (e.
PDGFR-B can also bind to ITGB3 to promote EC proliferation and migration (Borges et al.
2005) Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Moreover, the recovery of DEFA3, HBB, ITGA2B, and ITGB3 mRNAs in EMV preceded the recovery of white blood cell (WBC), reticulocyte, and platelet counts in the CBC (Fig.
4] Human genes: ACTB, actin, beta; B2M, beta-2-microglubulin; DEFA3, defensin, alpha 3, neutrophil-specific; SRGN, serglycin; HBB, hemoglobin, beta; UROD, uroporphyrinogen decarboxylase; ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); CD34, CD34 molecule; CD3E, CD3e molecule, epsilon (CD3-TCR complex); CD4, CD4 molecule; CD8A, CD8a molecule; CD19, CD19 molecule.
In the present study, we compared the frequencies of FV Leiden, FV 4070A/G, FV 5279A/G, FXIII 103G/T, FXIII 614A/T, FXIII 1694C/T, BF -455G/A, PAI-1-4G/5G, ITGB3 1565T/C, MTHFR 677C/T, and MTHFR 1298A/C polymorphisms and their combinations in patients with RPL and the control group.
A genetic variation in the ITGB3 gene that involves a single amino-acid substitution of proline for leucine at position 33 has been related to increased platelet aggregation.
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.
Ten are of known function [GJA1, ITGB3, collagen type I alpha 1 (COL1A1), IGFBP5, MMP2, myosin light polypeptide kinase (MYLK), GATA binding protein 6 (GATA6), chemokine (C-C motif) ligand 2 (CCL2), protein kinase C alpha (PRKCA), and nudeoporin (NUP88)], and one has unknown function.
Molecular analysis is available for identifying mutations in the ITGA2B and ITGB3 [integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)] genes and is important for genetic counseling.