ITGB3

ITGB3

A gene on chromosome 17q25 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-3 chain partners with the alpha-IIb chain and acts as a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, vitronectin and platelets. Beta-3 chain partnered with the alpha-5 chain is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
References in periodicals archive ?
ITGAV, ITGB3, beta-catenin and PECAM1), tubule formation factors (e.
PDGFR-B can also bind to ITGB3 to promote EC proliferation and migration (Borges et al.
Moreover, the recovery of DEFA3, HBB, ITGA2B, and ITGB3 mRNAs in EMV preceded the recovery of white blood cell (WBC), reticulocyte, and platelet counts in the CBC (Fig.
4] Human genes: ACTB, actin, beta; B2M, beta-2-microglubulin; DEFA3, defensin, alpha 3, neutrophil-specific; SRGN, serglycin; HBB, hemoglobin, beta; UROD, uroporphyrinogen decarboxylase; ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); CD34, CD34 molecule; CD3E, CD3e molecule, epsilon (CD3-TCR complex); CD4, CD4 molecule; CD8A, CD8a molecule; CD19, CD19 molecule.
In the present study, we compared the frequencies of FV Leiden, FV 4070A/G, FV 5279A/G, FXIII 103G/T, FXIII 614A/T, FXIII 1694C/T, BF -455G/A, PAI-1-4G/5G, ITGB3 1565T/C, MTHFR 677C/T, and MTHFR 1298A/C polymorphisms and their combinations in patients with RPL and the control group.
Genotype Analysis: Polymerase chain reaction (PCR) amplification of DNA samples was performed using FV Leiden, FV 4070A/G, FV 5279 A/G, FXIII 103G/T, FXIII 614A/T, FXIII 1694C/T, BF -455G/A, PAI-1 -4G/5G, ITGB3 1565T/C, MTHFR 677C/T, and MTHFR 1298A/C polymorphism specific primers (7, 25, 26).
ITGB3 1565T/C: The ITGB3 1565T/C genotype distribution significantly differed between the case and control groups, However, the variant genotypes were more frequent in the control group (p <0.
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.
Ten are of known function [GJA1, ITGB3, collagen type I alpha 1 (COL1A1), IGFBP5, MMP2, myosin light polypeptide kinase (MYLK), GATA binding protein 6 (GATA6), chemokine (C-C motif) ligand 2 (CCL2), protein kinase C alpha (PRKCA), and nudeoporin (NUP88)], and one has unknown function.
III] Chemokine (C-C motif) ligand 2 CCL2 Cell-cell signaling Collagen, type I, alpha 1 COL1A1 Extracellular matrix Connexin 43 GJA1 Cell-cell signaling GATA binding protein 6 GATA6 Transcription factor activity Insulin-like growth factor IGFBP5 Regulation of binding protein 5 cell growth Integrin, beta 3 ITGB3 Cell-matrix adhesion Matrix metalloproteinase 2 MMP2 Metallopeptidase activity Myosin, light polypeptide kinase MYLK Protein kinase activity Nucleoporin 88 kDa NUP88 Nuclear pore Protein kinase C, alpha PRKCA Cell proliferation Homo sapiens PAC clone RP5-1057Ml Unknown from 7, complete sequence [MMA.
Molecular analysis is available for identifying mutations in the ITGA2B and ITGB3 [integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)] genes and is important for genetic counseling.
Glanzmann thrombasthenia; a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models.