ISG15

ISG15

A gene on chromosome 1p36.33 that encodes a ubiquitin-like protein which binds to target proteins in response to IFN-alpha or IFN-beta stimulation. ISG15 has chemotactic activity on neutrophils and activates them, triggering their release of eosinophil chemotactic factors. It may: play a role as a trans-acting binding factor, directing ligated target proteins to bind to intermediate filaments; have autocrine, paracrine and endocrine effects, including cell-to-cell signalling, possibly by inducing IFN-gamma secretion by macrophages; respond to IFN-tau secreted by the foetus; and bind and regulate proteins involved in the release of prostaglandin F2-alpha, preventing lysis of the corpus luteum and maintaining the pregnancy.
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Mendelian Susceptibility to Mycobacterial Diseases MSMD has especially been associated with defects in the IL12B, IL12RB1, IRF8, ISG15, NEMO, IFNGR1, IFNGR2, STAT1, IRF8, and CYBB genes (15-22).
Genetic disorders associated with inborn errors in IFN-[gamma]-dependent immunity include those which impair production of IFN-[gamma] (IL12B, IL12RB1, IRF8, ISG15, NEMO) and those which impair response to IFN-[gamma] (IFNGR1, IFNGR2, STAT1, IRF8, CYBB) [2].
Diversity of ubiquitin and ISG15 specificity among nairoviruses' viral ovarian tumor domain proteases.
Contudo, a infusao continua de roIFN-[TAU] na veia uterina resultou em maior expressao de ISG15 luteal quando comparada a injecao unica na arteria ovariana (10) e induziu nos animais tratados o prolongamento do intervalo entre estros e a manutencao de elevadas concentrares sericas de progesterona por ate para 32 dias.
Mesecar and his team captured the molecular structure of a key SARS enzyme, papain-like protease, and revealed how it strips a host cell of the proteins ubiquitin and ISG15, which are involved in triggering an immune response.
TANK (also known as I-TRAF) is a negative regulator of TLR-mediated proinflammatory cytokines, such as IL6 and TNF[alpha], but not ISGs, such as ISG15, through the suppression of TRAF6.
The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
A ISG15 (gene estimulado por inteferon 15) e uma proteina que possui funcao semelhante a uma ubiquitina (AUSTIN et al.
OTCBB: ADXS), a leader in developing the next generation of immunotherapies for cancer and infectious diseases, has exclusively licensed the use of antigen ISG15 in Advaxis' Lm-LLO based immunotherapies from the University of Pennsylvania.
ISG15 is induced as a disease resistance gene and expressed efficiently in mammalian cells after stimuli with IFNs and viruses (Der et al.