ISG15

ISG15

A gene on chromosome 1p36.33 that encodes a ubiquitin-like protein which binds to target proteins in response to IFN-alpha or IFN-beta stimulation. ISG15 has chemotactic activity on neutrophils and activates them, triggering their release of eosinophil chemotactic factors. It may: play a role as a trans-acting binding factor, directing ligated target proteins to bind to intermediate filaments; have autocrine, paracrine and endocrine effects, including cell-to-cell signalling, possibly by inducing IFN-gamma secretion by macrophages; respond to IFN-tau secreted by the foetus; and bind and regulate proteins involved in the release of prostaglandin F2-alpha, preventing lysis of the corpus luteum and maintaining the pregnancy.
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Mesecar and his team captured the molecular structure of a key SARS enzyme, papain-like protease, and revealed how it strips a host cell of the proteins ubiquitin and ISG15, which are involved in triggering an immune response.
ISG15 is induced as a disease resistance gene and expressed efficiently in mammalian cells after stimuli with IFNs and viruses (Der et al.
However, there are no reports regarding the ISG15 sequence of Xinjiang Wild Argali.
The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
The NS1 of both influenza A and B viruses prevents the activation of the translation inhibitory and IFN inducible protein PKR (25,26); the NS1 of influenza B virus inhibits the activity of ISG15 (27), an IFN-inducible protein that enhances the IFN-mediated antiviral response.
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.
OTCBB: ADXS), a leader in developing the next generation of immunotherapies for cancer and infectious diseases, has exclusively licensed the use of antigen ISG15 in Advaxis' Lm-LLO based immunotherapies from the University of Pennsylvania.
The aim of this study was to characterize the response patterns of ISG12, ISG15, MX1, and MX2 after exposure to bovine IFNs (bIFNs)-IFNT1, IFNTc1, and IFNA-in uterine epithelial and Mardin-Darby bovine kidney (MDBK) cells.
Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer, but how the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear.
This research by Shyamal Desai, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans found that a cellular defense system called the ISG15 pathway, which is normally involved in fighting bacterial and viral infection, is triggered in breast cancer to disrupt normal cytoskeletal function and increase the possibility that the cancer cells will metastasize, or spread.
Low blood ISG15 mRNA and progesterone levels are predictive of non-pregnant dairy cows.
That human protein, known as interferon-stimulated gene 15 protein or ISG15, is an essential part of the defence mechanism that human cells use to protect themselves from viral infections.