IRS2

IRS2

A gene on chromosome 13q34 that encodes a cytoplasmic signalling protein phosphorylated by insulin receptor tyrosine kinase; it mediates the effects of insulin, insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between various receptor tyrosine kinases and downstream effectors.
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Using comparative transcriptomics in two model plant species I have identified a small family of genes (IRS1, IRS2 and BTS) that are good candidates for the plant Fe sensors.
21] Furthermore, a study that investigated the development of diabetes in mice with three mutations in the insulin receptor, IRS1 and IRS2 reported a higher prevalence (40%) of progression to diabetes in mice with all three mutations compared with mice carrying one mutation (5%).
The engineered mice had just one copy of a gene called IRS2 in their brain cells instead of the normal two, explains Morris F.
He is particularly interested in the IGF family of growth factors, their intracellular signaling molecules such as IRS1 and IRS2, and their roles in mammary gland development and breast cancer.
Varying effects occurred with the knockout of genes for IRS2, IRS3 and IRS4.
Epigallocatechin gallate (EGCG) and rutin suppress the glu-cotoxicity through activating IRS2 and AMPK signalling in pancreatic rat 13 cells.
Brain IRS2 signaling coordinates life span and nutrient homeostasis.