IRS-2


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IRS-2

IRS2

A gene on chromosome 13q34 that encodes a cytoplasmic signalling protein phosphorylated by insulin receptor tyrosine kinase; it mediates the effects of insulin, insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between various receptor tyrosine kinases and downstream effectors.
References in periodicals archive ?
Time will tell how relevant IRS-2 is to the human condition," says Graeme I.
Preliminary investigations have hinted that some people with type 2 diabetes have altered IRS-2 activity, White counters.
White suggests that stimulating IRS-2 activity could offer a treatment for either type of diabetes.